Palladium-Catalyzed Enantioselective Domino Reaction for the Efficient Synthesis of Vitamin E

A new route to vitamin E: The palladium‐catalyzed enantioselective domino reaction of the unsaturated phenol derivative 1 with acrylate provides efficient access to the chiral chroman 2 with 96 % ee and in 84 % yield (see scheme). Intermediate 2 can then be converted into vitamin E in a few steps....

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Veröffentlicht in:	Angewandte Chemie International Edition 2004-12, Vol.44 (2), p.257-259
Hauptverfasser:	Tietze, Lutz F., Sommer, Konrad M., Zinngrebe, Julia, Stecker, Florian
Format:	Artikel
Sprache:	eng
Schlagworte:	asymmetric catalysis Catalysis domino reactions Heck reactions Molecular Structure palladium Palladium - chemistry Stereoisomerism Vitamin E - chemical synthesis Vitamin E - chemistry vitamins Wacker oxidation
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	A new route to vitamin E: The palladium‐catalyzed enantioselective domino reaction of the unsaturated phenol derivative 1 with acrylate provides efficient access to the chiral chroman 2 with 96 % ee and in 84 % yield (see scheme). Intermediate 2 can then be converted into vitamin E in a few steps.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200461629