Structural flexibility of small GTPases. Can it explain their functional versatility?

Multiple interactions with many different partners are responsible for the amazing functional versatility of proteins, especially those participating in cellular regulation. The structural properties that could facilitate multiple interactions are examined for small GTPases. The role of cellular con...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biological chemistry 2004-12, Vol.385 (12), p.1121-1136
1. Verfasser:	Helmreich, Ernst J M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cellular constraints coupling versatility flexible proteins Genes, ras - physiology GTP Phosphohydrolases - chemistry GTP Phosphohydrolases - metabolism GTP-Binding Proteins - metabolism GTPase structure Humans Models, Molecular Molecular Weight Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-raf - physiology ran GTP-Binding Protein - physiology Receptor Cross-Talk - physiology small GTPases
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Multiple interactions with many different partners are responsible for the amazing functional versatility of proteins, especially those participating in cellular regulation. The structural properties that could facilitate multiple interactions are examined for small GTPases. The role of cellular constraints, compartmentation and scaffolds on protein-protein interactions is considered.
ISSN:	1431-6730 1437-4315
DOI:	10.1515/BC.2004.146