Critical role for CD8+FoxP3+ regulatory T cells in colon cancer immune response in humans

Unfortunately, MMR status (routinely assessed by using immunohistochemistry and/or PCR) has not been characterised by Chaput et al, 8 and the level of IL17 in situ expression is not given in this study. [...]the increase in TGFβ1 and IL6 in their series cannot be correlated with the level of IL17 nor with the MMR status. A positive correlation between the number of antigen-presenting cells (APCs) and Foxp3+ T cells and an inverse relationship with the systemic TAA T cell response has been reported. 4 Therefore, it would also be of great interest to investigate the tumour-infiltrating myloid-derived suppressor cells with special reference to MMR status. 1 3 THE PLACE OF BLOOD IMMUNE MARKERS IN COLON CANCER Studies on peripheral blood cells are still preliminary, and pTNM staging still remains the best prognostic marker for treatment decision in the management of CRCs.