Free Colorectal Cancer Cells on the Peritoneal Surface: Correlation With Pathologic Variables and Survival

BACKGROUND: METHODS: RESULTS:Overall, 26 of 281 (9.25 percent) colorectal cancers had positive cytology for cancer cells on the peritoneal surface of the bowel. Poorly differentiated tumors were significantly associated with positive cytology. Tumor penetration, presence of vascular or neural invasi...

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Veröffentlicht in:	Diseases of the colon & rectum 2004-12, Vol.47 (12), p.2076-2079
Hauptverfasser:	Baskaranathan, Sriskanthan, Philips, Jeanette, McCredden, Pauline, Solomon, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - mortality Adenocarcinoma - pathology Adenocarcinoma - surgery Analysis of Variance Biological and medical sciences Cause of Death Cell Biology - standards Colectomy Colorectal cancer Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery Combined Modality Therapy Elective Surgical Procedures Gastroenterology. Liver. Pancreas. Abdomen Humans Medical sciences Monitoring, Intraoperative - methods Monitoring, Intraoperative - standards Neoplasm Recurrence, Local - etiology Neoplasm Recurrence, Local - mortality Neoplasm Seeding Neoplasm Staging New South Wales - epidemiology Patient Selection Peritoneum Predictive Value of Tests Prognosis Proportional Hazards Models Prospective Studies Registries Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Analysis Treatment Outcome Tumors
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Zusammenfassung:	BACKGROUND: METHODS: RESULTS:Overall, 26 of 281 (9.25 percent) colorectal cancers had positive cytology for cancer cells on the peritoneal surface of the bowel. Poorly differentiated tumors were significantly associated with positive cytology. Tumor penetration, presence of vascular or neural invasion, mucinous characteristics, lymph node status, and operative procedure performed were not statistically significant predictors of positive cytology. Overall, 43 of the 281 patients (15.3 percent) died during the mean follow-up period of 49.2 months from cancer-related deaths. Of these patients, 8 had positive cytology and 35 had negative cytology results. Cancer-specific survival assessed with the log-rank test was significantly associated with positive cytology in univariate (P = 0.008) and multivariate analysis (P < 0.001). CONCLUSION:
ISSN:	0012-3706 1530-0358
DOI:	10.1007/s10350-004-0723-8