Novel Cytotoxic Thiodiketopiperazine Derivatives from a Tilachlidium sp

Three novel thiodiketopiperazine derivatives, T988 A, B, and C (1−3), were isolated from a Tilachlidium sp. Their structures were elucidated by spectroscopic analyses using various 1D and 2D NMR techniques. All the compounds showed potent cytotoxicity against cultured P388 leukemia cells.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2004-12, Vol.67 (12), p.2090-2092
Hauptverfasser:	Feng, Yunjiang, Blunt, John W, Cole, Anthony L. J, Munro, Murray H. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Applied microbiology Biological and medical sciences Chemotherapic agents Drug Screening Assays, Antitumor Fundamental and applied biological sciences. Psychology Fungi - chemistry Leukemia P388 Mice Microbiology Molecular Structure New Zealand Nuclear Magnetic Resonance, Biomolecular Piperazines - chemistry Piperazines - isolation & purification Piperazines - pharmacology Tilachlidium Tumor Cells, Cultured
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Beschreibung
Zusammenfassung:	Three novel thiodiketopiperazine derivatives, T988 A, B, and C (1−3), were isolated from a Tilachlidium sp. Their structures were elucidated by spectroscopic analyses using various 1D and 2D NMR techniques. All the compounds showed potent cytotoxicity against cultured P388 leukemia cells.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np030326w