Ectopic expression of histone H2AX mutants reveals a role for its post-translational modifications

Recent evidence from a wide variety of biological systems has indicated important regulatory roles for post-translation histone modifications in cellular processes such as regulation of gene expression, DNA damage response and recombination. Phosphorylation of histone H2AX at serine 139 is a critica...

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Veröffentlicht in:	Cancer biology & therapy 2009-03, Vol.8 (5), p.422-434
Hauptverfasser:	Rios-Doria, Jonathan, Velkova, Aneliya, Dapic, Virna, Galán-Caridad, José M, Dapic, Vesna, Carvalho, Marcelo A, Melendez, Johana, Monteiro, Alvaro N A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Apoptosis - genetics Apoptosis - physiology Blotting, Western Cell Cycle - genetics Cell Cycle - physiology Cell Line Chromosome Aberrations Fluorescent Antibody Technique Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism HCT116 Cells HeLa Cells Histones - genetics Histones - metabolism Humans Immunoprecipitation Lysine - genetics Lysine - metabolism Mutation Phosphorylation Proteasome Endopeptidase Complex - metabolism Protein Processing, Post-Translational Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Serine - genetics Serine - metabolism Transfection Ubiquitination
Online-Zugang:	Volltext
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