Sesquiterpenes, lignans and other constituents from Saussurea macrota

From the methanol extract of the whole plant of Saussurea macrota Franch, 21 compounds were isolated. Their structures were elucidated by spectroscopic methods and X-ray crystallography. Two of them are new: 3α-hydroxy-11αH-guaia-4(15),10(14)-diene-12,6α-olide (1) and 7′-hydroxyiso-lappaol A (11). C...

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Veröffentlicht in:	Pharmazie 2004-12, Vol.59 (12), p.972-976
Hauptverfasser:	Yang, Min, Wang, Chun-Ming, Zhang, Qi, Han, Yi-Feng, Jia, Zhong-Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - pharmacology Bacteria - drug effects Cell Line, Tumor Crystallography, X-Ray Drug Screening Assays, Antitumor Humans Lignans - analysis Lignans - pharmacology Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Plant Extracts - chemistry Plant Extracts - pharmacology Protein Conformation Saussurea - chemistry Sesquiterpenes - analysis Sesquiterpenes - pharmacology Spectrophotometry, Infrared
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Zusammenfassung:	From the methanol extract of the whole plant of Saussurea macrota Franch, 21 compounds were isolated. Their structures were elucidated by spectroscopic methods and X-ray crystallography. Two of them are new: 3α-hydroxy-11αH-guaia-4(15),10(14)-diene-12,6α-olide (1) and 7′-hydroxyiso-lappaol A (11). Compound 2 is reported as a natural compound for the first time. In addition, the compounds 12 and 13 showed significant antitumor activity against Bel-7402 and HO-8910 cells. Some of the compounds exhibited weak antibacterial activity against Staphylococcus aureus, Bacillus subtilis and Escherichia coli.
ISSN:	0031-7144