Comparative effects of high glucose on different adult sympathetic neurons in culture

In vivo, diabetes causes neuropathy in the sympathetic celiac/superior mesenteric ganglion (CG/SMG) but not the superior cervical ganglion (SCG). Therefore, our aim was to compare the effects of high glucose in vitro on adult rat SCG and CG/SMG neurons. High glucose decreased viability and neurite o...

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Veröffentlicht in:	Neuroreport 2004-10, Vol.15 (15), p.2321-2325
Hauptverfasser:	Semra, Yemane K, Smith, Neil C. E, Lincoln, Jill
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Associated diseases and complications Biological and medical sciences Cell Count - methods Cell Death - drug effects Cells, Cultured Diabetes. Impaired glucose tolerance Dose-Response Relationship, Drug Endocrine pancreas. Apud cells (diseases) Endocrinopathies Ganglia, Sympathetic - cytology Glucose - pharmacology Immunohistochemistry - methods In Situ Nick-End Labeling - methods Male Medical sciences Neurites - drug effects Neurons - drug effects Neurons - metabolism Propidium - metabolism Rats Rats, Sprague-Dawley Time Factors Ubiquitin Thiolesterase - metabolism
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Zusammenfassung:	In vivo, diabetes causes neuropathy in the sympathetic celiac/superior mesenteric ganglion (CG/SMG) but not the superior cervical ganglion (SCG). Therefore, our aim was to compare the effects of high glucose in vitro on adult rat SCG and CG/SMG neurons. High glucose decreased viability and neurite outgrowth and increased TUNEL staining in freshly dissociated neurons from both ganglia. In cultures established for 24 h before exposure to high glucose, a significant (p
ISSN:	0959-4965 1473-558X
DOI:	10.1097/00001756-200410250-00004