A-503083 A, B, E and F, Novel Inhibitors of Bacterial Translocase I, Produced by Streptomyces sp. SANK 62799
Novel nucleoside antibiotics were isolated from the cultured broth of the strain classified as Streptomyces sp. SANK 62799. The strain produced four novel capuramycin derivatives designated as A-503083 A, B, E and F. Their structures were elucidated as 2'-O-carbamoyl derivatives of A-500359 A,...
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| Veröffentlicht in: | Journal of antibiotics 2004/10/25, Vol.57(10), pp.639-646 |
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| container_title | Journal of antibiotics |
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| creator | MURAMATSU, YASUNORI OHNUKI, TAKASHI ISHII, MICHIKO MIYAZAWA KIZUKA, MASAAKI ENOKITA, RYUZO MIYAKOSHI, SHUNICHI TAKATSU, TOSHIO INUKAI, MASATOSHI |
| description | Novel nucleoside antibiotics were isolated from the cultured broth of the strain classified as Streptomyces sp. SANK 62799. The strain produced four novel capuramycin derivatives designated as A-503083 A, B, E and F. Their structures were elucidated as 2'-O-carbamoyl derivatives of A-500359 A, B (capuramycin), E and F, respectively. A-503083 A, B, E and F inhibited bacterial phospho-N-acetylmuramyl-pentapeptide-translocase (translocase I: EC 2.7.8.13) with IC50 values of 0.024, 0.038, 0.135 and 17.9μM, respectively. |
| doi_str_mv | 10.7164/antibiotics.57.639 |
| format | Article |
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A-503083 A, B, E and F inhibited bacterial phospho-N-acetylmuramyl-pentapeptide-translocase (translocase I: EC 2.7.8.13) with IC50 values of 0.024, 0.038, 0.135 and 17.9μM, respectively.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.57.639</identifier><identifier>PMID: 15638324</identifier><language>eng</language><publisher>Japan: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject><![CDATA[Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - isolation & purification ; Anti-Bacterial Agents - pharmacology ; Azepines - chemistry ; Azepines - isolation & purification ; Azepines - pharmacology ; Bacteria - enzymology ; Enzyme Inhibitors - chemistry ; Enzyme Inhibitors - isolation & purification ; Enzyme Inhibitors - pharmacology ; Streptomyces - classification ; Streptomyces - metabolism ; Transferases (Other Substituted Phosphate Groups) - antagonists & inhibitors ; Uridine - analogs & derivatives ; Uridine - chemistry ; Uridine - isolation & purification ; Uridine - pharmacology]]></subject><ispartof>The Journal of Antibiotics, 2004/10/25, Vol.57(10), pp.639-646</ispartof><rights>Japan Antibiotics Research Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c609t-112313d9d1c3136c904bc67e7053fbddc087bc478a25c0031d23eb32d16268493</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15638324$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MURAMATSU, YASUNORI</creatorcontrib><creatorcontrib>OHNUKI, TAKASHI</creatorcontrib><creatorcontrib>ISHII, MICHIKO MIYAZAWA</creatorcontrib><creatorcontrib>KIZUKA, MASAAKI</creatorcontrib><creatorcontrib>ENOKITA, RYUZO</creatorcontrib><creatorcontrib>MIYAKOSHI, SHUNICHI</creatorcontrib><creatorcontrib>TAKATSU, TOSHIO</creatorcontrib><creatorcontrib>INUKAI, MASATOSHI</creatorcontrib><title>A-503083 A, B, E and F, Novel Inhibitors of Bacterial Translocase I, Produced by Streptomyces sp. 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A-503083 A, B, E and F inhibited bacterial phospho-N-acetylmuramyl-pentapeptide-translocase (translocase I: EC 2.7.8.13) with IC50 values of 0.024, 0.038, 0.135 and 17.9μM, respectively.</description><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Azepines - chemistry</subject><subject>Azepines - isolation & purification</subject><subject>Azepines - pharmacology</subject><subject>Bacteria - enzymology</subject><subject>Enzyme Inhibitors - chemistry</subject><subject>Enzyme Inhibitors - isolation & purification</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Streptomyces - classification</subject><subject>Streptomyces - metabolism</subject><subject>Transferases (Other Substituted Phosphate Groups) - antagonists & inhibitors</subject><subject>Uridine - analogs & derivatives</subject><subject>Uridine - chemistry</subject><subject>Uridine - isolation & purification</subject><subject>Uridine - pharmacology</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkE1vEzEQhi0EoqHwBzigOXHKBn_s-uOYVi1ELQWp5Wx57QndarMOtlMp_x5XidpeZi7PPK_mJeQzowvFZPvNTWXoh1gGnxedWkhh3pAZ05o1rJXmLZlRylmjNacn5EPOD5QKJZR-T05YJ4UWvJ2Rcdl0VFAtYDmHszlcgJsCXM7hJj7iCKvpvkaUmDLENZw5XzANboS75KY8Ru8ywmoOv1MMO48B-j3cloTbEjd7jxnydgG3y5srkFwZ85G8W7sx46fjPiV_Li_uzn8017--r86X142X1JSGMS6YCCYwX7f0hra9lwoV7cS6D8FTrXrfKu145-tTLHCBveCBSS51a8Qp-XrwblP8t8Nc7GbIHsfRTRh32UrFKVedqiA_gD7FnBOu7TYNG5f2llH71LF91bHtlK0d16MvR_uu32B4OTmWWoGfB-AhF_cXnwGXqmbE105mpH7y1rjDrAHPnL93yeIk_gPIW5HW</recordid><startdate>2004</startdate><enddate>2004</enddate><creator>MURAMATSU, YASUNORI</creator><creator>OHNUKI, TAKASHI</creator><creator>ISHII, MICHIKO MIYAZAWA</creator><creator>KIZUKA, MASAAKI</creator><creator>ENOKITA, RYUZO</creator><creator>MIYAKOSHI, SHUNICHI</creator><creator>TAKATSU, TOSHIO</creator><creator>INUKAI, MASATOSHI</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2004</creationdate><title>A-503083 A, B, E and F, Novel Inhibitors of Bacterial Translocase I, Produced by Streptomyces sp. 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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Azepines - chemistry Azepines - isolation & purification Azepines - pharmacology Bacteria - enzymology Enzyme Inhibitors - chemistry Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology Streptomyces - classification Streptomyces - metabolism Transferases (Other Substituted Phosphate Groups) - antagonists & inhibitors Uridine - analogs & derivatives Uridine - chemistry Uridine - isolation & purification Uridine - pharmacology |
| title | A-503083 A, B, E and F, Novel Inhibitors of Bacterial Translocase I, Produced by Streptomyces sp. SANK 62799 |
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