A-503083 A, B, E and F, Novel Inhibitors of Bacterial Translocase I, Produced by Streptomyces sp. SANK 62799

Novel nucleoside antibiotics were isolated from the cultured broth of the strain classified as Streptomyces sp. SANK 62799. The strain produced four novel capuramycin derivatives designated as A-503083 A, B, E and F. Their structures were elucidated as 2'-O-carbamoyl derivatives of A-500359 A,...

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Veröffentlicht in:	Journal of antibiotics 2004/10/25, Vol.57(10), pp.639-646
Hauptverfasser:	MURAMATSU, YASUNORI, OHNUKI, TAKASHI, ISHII, MICHIKO MIYAZAWA, KIZUKA, MASAAKI, ENOKITA, RYUZO, MIYAKOSHI, SHUNICHI, TAKATSU, TOSHIO, INUKAI, MASATOSHI
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Azepines - chemistry Azepines - isolation & purification Azepines - pharmacology Bacteria - enzymology Enzyme Inhibitors - chemistry Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology Streptomyces - classification Streptomyces - metabolism Transferases (Other Substituted Phosphate Groups) - antagonists & inhibitors Uridine - analogs & derivatives Uridine - chemistry Uridine - isolation & purification Uridine - pharmacology
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Zusammenfassung:	Novel nucleoside antibiotics were isolated from the cultured broth of the strain classified as Streptomyces sp. SANK 62799. The strain produced four novel capuramycin derivatives designated as A-503083 A, B, E and F. Their structures were elucidated as 2'-O-carbamoyl derivatives of A-500359 A, B (capuramycin), E and F, respectively. A-503083 A, B, E and F inhibited bacterial phospho-N-acetylmuramyl-pentapeptide-translocase (translocase I: EC 2.7.8.13) with IC50 values of 0.024, 0.038, 0.135 and 17.9μM, respectively.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.57.639