Effects of Focused Ultrasound Sonodynamic Treatment on the Rat Blood-Brain Barrier
Background: Ultrasound has recently been applied to the treatment as well as the diagnosis of various pathologies, and its antitumor effects in the treatment of human cancer and experimental models of cancer have been demonstrated. In addition, it is possible that certain photosensitizers will enhan...
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Veröffentlicht in: | Anticancer research 2009-03, Vol.29 (3), p.889-895 |
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Sprache: | eng |
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Zusammenfassung: | Background: Ultrasound has recently been applied to the treatment as well as the diagnosis of various pathologies, and its
antitumor effects in the treatment of human cancer and experimental models of cancer have been demonstrated. In addition,
it is possible that certain photosensitizers will enhance the antitumor effects of ultrasound. However, very few studies have
been reported on how the blood-brain barrier is affected by sonodynamic therapy. The purpose of this study was to evaluate
disruption of the blood-brain barrier with focused ultrasound with a photosensitizer, for clinical application of sonodynamic
therapy to brain tumors. Materials and Methods: Rat brains were subjected to focused ultrasound irradiation via a transducer
with or without prior intravenous injection of photosensitizer, and lesions were examined histologically by electron microscopy.
Results: Electron microscopically, swelling of astroglial processes, denatured cells, protoplasm of endothelial cells, and
mitochondria were observed in the center and border of regions of ultrasonic irradiation. There were numerous pinocytotic
vesicles in the cytoplasm of the endothelial cells. In addition, disruption of the cytoplasmic membrane of endothelial cells
and astroglia was found in these regions. Conclusion: These findings suggest that sonodynamic therapy with a photosensitizer
affects the blood-brain barrier, and that blood vessel permeability increases not only as a result of destruction of the blood-brain
barrier but also by disruption of the cytoplasmic membrane of endothelial cells. |
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ISSN: | 0250-7005 1791-7530 |