Influence of various antimicrobial agents on the intestinal flora in an intestinal MRSA-carrying rat model

Using an intestinal methicillin-resistant Staphylococcus aureus (MRSA)-carrying rat model, we compared the influence of piperacillin (PIPC) on the intestinal flora to those of cefazolin (CEZ), cefmetazole (CMZ), and flomoxef (FMOX). The number of MRSA did not increase after PIPC and CEZ administrati...

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Veröffentlicht in:	Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2004-12, Vol.10 (6), p.338-342
Hauptverfasser:	Takahata, Masahiro, Sugiura, Yoko, Ameyama, Satoshi, Mitsuyama, Junichi, Yotsuji, Akira, Sumiyama, Yoshinobu, Kusachi, Shinya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal model Animals Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Bacteroides Bacteroides - drug effects Disease Models, Animal Escherichia coli Escherichia coli - drug effects Feces - microbiology Intestinal flora Male Methicillin Resistance Microbial Sensitivity Tests MRSA Rats Rats, Wistar Staphylococcal Infections - drug therapy Staphylococcal Infections - microbiology Staphylococcus aureus
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Zusammenfassung:	Using an intestinal methicillin-resistant Staphylococcus aureus (MRSA)-carrying rat model, we compared the influence of piperacillin (PIPC) on the intestinal flora to those of cefazolin (CEZ), cefmetazole (CMZ), and flomoxef (FMOX). The number of MRSA did not increase after PIPC and CEZ administrations compared with the nontreated group. However, it significantly increased in the cases of FMOX and CMZ administration (P
ISSN:	1341-321X 1437-7780
DOI:	10.1007/s10156-004-0346-Y