Illuminating Zinc in Biological Systems

Zinc is the second most abundant transition metal in the human body, fulfilling a multitude of biological roles, but the mechanisms underlying its physiology are poorly understood. The lack of knowledge is, in part, due to the hitherto limited techniques available to track zinc in biological systems. The recent emergence of a number of zinc‐specific molecular sensors has provided a new tool to image zinc in live cells and tissue samples. This contribution highlights the concepts behind using zinc‐specific fluorescent molecular sensors to gain information about zinc action in biological samples, and provides representative examples of images recorded. Zinc illumination: The recent emergence of Zn2+‐specific molecular sensors has provided a new tool to image zinc in live cells and tissue samples, suitable to garner information about the not well understood biochemistry of this ubiquitous trace metal ion. A schematic representation of a fluorescent molecular metal sensor is illustrated here.