Growth factor-driven mechanisms associated with resistance to estrogen deprivation in breast cancer: new opportunities for therapy

There is an increasing body of evidence demonstrating that elevated growth signaling in breast cancer cells can promote forms of endocrine resistance in either an estrogen receptor-dependent or -independent manner. The current article reviews what is known about such growth factor signaling networks...

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Veröffentlicht in:	Endocrine-related cancer 2004-12, Vol.11 (4), p.623-641
Hauptverfasser:	Nicholson, R I, Staka, C, Boyns, F, Hutcheson, I R, Gee, J M W
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Drug Resistance, Neoplasm Estrogens - metabolism Female Growth Substances - metabolism Humans Receptors, Estrogen - metabolism Reviews Signal Transduction
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Beschreibung
Zusammenfassung:	There is an increasing body of evidence demonstrating that elevated growth signaling in breast cancer cells can promote forms of endocrine resistance in either an estrogen receptor-dependent or -independent manner. The current article reviews what is known about such growth factor signaling networks and resistance to estrogen withdrawal and considers the many novel therapeutic opportunities that stem from this knowledge.
ISSN:	1351-0088 1479-6821
DOI:	10.1677/erc.1.00778