Improvement of nisin production in pH feed-back controlled, fed-batch culture by Lactococcus lactis subsp. lactis

Nisin production by Lactococcus lactis subsp. lactisin fed-batch culture was doubled by using a pH feed-back controlled method. Sucrose concentration was controlled at 10 g l-1 giving 5010 IU nisin ml-1 compared to 2660 IU nisin ml-1 in batch culture.

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Bibliographische Detailangaben
Veröffentlicht in:	Biotechnology letters 2004-11, Vol.26 (22), p.1713-1716
Hauptverfasser:	Lv, W, Cong, W, Cai, Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Biological and medical sciences biological production Bioreactors - microbiology biosynthesis Biotechnology Cell Culture Techniques - methods Cell Proliferation Feedback - physiology Fundamental and applied biological sciences. Psychology Hydrogen-Ion Concentration lactic acid bacteria lactic fermentation Lactococcus lactis Lactococcus lactis - chemistry Lactococcus lactis - growth & development Lactococcus lactis - metabolism nisin Nisin - biosynthesis Sucrose - metabolism
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Beschreibung
Zusammenfassung:	Nisin production by Lactococcus lactis subsp. lactisin fed-batch culture was doubled by using a pH feed-back controlled method. Sucrose concentration was controlled at 10 g l-1 giving 5010 IU nisin ml-1 compared to 2660 IU nisin ml-1 in batch culture.
ISSN:	0141-5492 1573-6776
DOI:	10.1007/s10529-004-3742-6