MATERNALLY DERIVED ANTIBODIES AGAINST BORDETELLA PERTUSSIS ANTIGENS PERTUSSIS TOXIN AND FILAMENTOUS HEMAGGLUTININ IN PRETERM AND FULL TERM NEWBORNS

MATERNALLY DERIVED ANTIBODIES AGAINST BORDETELLA PERTUSSIS ANTIGENS PERTUSSIS TOXIN AND FILAMENTOUS HEMAGGLUTININ IN PRETERM AND FULL TERM NEWBORNS

We measured IgG-anti–pertussis toxin and –IgG-anti–filamentous hemagglutinin antibody values in 43 full term and 34 preterm infants and 79 mothers. Antibody values were generally low and mean values were higher in full term than preterm infants. Transfer ratios increased with gestational age of the...

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Veröffentlicht in:The Pediatric infectious disease journal 2009-05, Vol.28 (5), p.443-445
Hauptverfasser: Heininger, Ulrich, Riffelmann, Marion, Leineweber, Birgit, Wirsing von Koenig, Carl Heinz
Format: Artikel
Sprache:eng
Schlagworte:
Adhesins, Bacterial - immunology
Antibodies, Bacterial - blood
Bordetella pertussis - immunology
Female
Humans
Immunity, Maternally-Acquired
Infant, Newborn
Infant, Premature - blood
Pertussis Toxin - immunology
Pregnancy
Virulence Factors, Bordetella - immunology
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Zusammenfassung:We measured IgG-anti–pertussis toxin and –IgG-anti–filamentous hemagglutinin antibody values in 43 full term and 34 preterm infants and 79 mothers. Antibody values were generally low and mean values were higher in full term than preterm infants. Transfer ratios increased with gestational age of the newborns. Based on these findings, maternal and neonatal immunization strategies should be considered to protect young infants from pertussis.
ISSN:0891-3668
1532-0987
DOI:10.1097/INF.0b013e318193ead7