Improving Implant Materials by Coating with Nonpeptidic, Highly Specific Integrin Ligands

Giving cells some stick: Osteoblast adhesion to titanium, a common material for implants, is stimulated by coating with an optimized and highly specific nonpeptidic ligand for the αvβ3 integrin (see picture). This new technology is advantageous to conventional coating by peptides or proteins in many...

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Veröffentlicht in:	Angewandte Chemie International Edition 2004-12, Vol.43 (48), p.6649-6652
Hauptverfasser:	Dahmen, Claudia, Auernheimer, Jörg, Meyer, Axel, Enderle, Anja, Goodman, Simon L., Kessler, Horst
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomimetic Materials - chemical synthesis Biomimetic Materials - chemistry Cell Adhesion cell recognition Coated Materials, Biocompatible - chemical synthesis Coated Materials, Biocompatible - chemistry Hydrazines - chemical synthesis Hydrazines - chemistry Integrin alphaV - chemistry Integrin alphaV - metabolism Ligands materials science Mice Models, Molecular Oligopeptides - chemistry Osteoblasts - cytology peptide mimetics Prostheses and Implants titanium Titanium - chemistry
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Beschreibung
Zusammenfassung:	Giving cells some stick: Osteoblast adhesion to titanium, a common material for implants, is stimulated by coating with an optimized and highly specific nonpeptidic ligand for the αvβ3 integrin (see picture). This new technology is advantageous to conventional coating by peptides or proteins in many practical aspects (selectivity and activity, stability against enzymatic degradation, sterilization, costs).
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200460770