Enantioselective Synthesis of Cyclopropanes by Aldehyde Homologation

Enantioselective Synthesis of Cyclopropanes by Aldehyde Homologation

An efficient method for the enantioselective preparation of structurally diverse cyclopropanes has been developed. Sequential homoaldol coupling and activation steps result in a three‐carbon homologation of an aldehyde to give a nonracemic, stereochemically rich cyclopropylcarboxaldehyde (see scheme...

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Veröffentlicht in:Angewandte Chemie International Edition 2004-12, Vol.43 (48), p.6671-6672
Hauptverfasser: Risatti, Christina A., Taylor, Richard E.
Format: Artikel
Sprache:eng
Schlagworte:
cations
cyclization
cyclopropanes
small ring systems
synthetic methods
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Zusammenfassung:An efficient method for the enantioselective preparation of structurally diverse cyclopropanes has been developed. Sequential homoaldol coupling and activation steps result in a three‐carbon homologation of an aldehyde to give a nonracemic, stereochemically rich cyclopropylcarboxaldehyde (see scheme).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200461106