Histamine H3-receptor isoforms
Increasing evidence supports a role for HA as a neurotransmitter and neuromodulator in various brain functions, including emotion, cognition, and feeding. The recent cloning of the histamine H3 receptor allowed for the subsequent cloning of a variety of H3 receptor isoforms from different species as...
Gespeichert in:
| Veröffentlicht in: | Inflammation research 2004-10, Vol.53 (10), p.509-516 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 516 |
|---|---|
| container_issue | 10 |
| container_start_page | 509 |
| container_title | Inflammation research |
| container_volume | 53 |
| creator | Bakker, R A |
| description | Increasing evidence supports a role for HA as a neurotransmitter and neuromodulator in various brain functions, including emotion, cognition, and feeding. The recent cloning of the histamine H3 receptor allowed for the subsequent cloning of a variety of H3 receptor isoforms from different species as well as the H4 receptor. As a result a wide variety of H3-receptor isoforms are now known that display differential brain expression patterns and signalling properties. These recent discoveries are discussed in view of the growing interest of the H3 receptor as a target for the development of potential therapeutics. |
| doi_str_mv | 10.1007/s00011-004-1286-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67165274</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>765842691</sourcerecordid><originalsourceid>FETCH-LOGICAL-c241t-ac452260d2da27d58ee1c7fb5407295d77cbabbd9e1284ffc9fa924582f130183</originalsourceid><addsrcrecordid>eNpdkMFKAzEURYMotlY_wE0pLtxF816SSbKUolYouFFwFzKZBKZ0OjWZWfj3prQguHpvce7lcgi5BfYAjKnHzBgDoIwJCqgras7IFAQyapj-Oi8_Q0655mxCrnLeFFqjxksyASmNAiGmZL5q8-C6dhcWK05T8GE_9GnR5j72qcvX5CK6bQ43pzsjny_PH8sVXb-_vi2f1tSjgIE6LyRixRpsHKpG6hDAq1hLwRQa2Sjla1fXjQllp4jRm-gMCqkxAmeg-YzcH3v3qf8eQx5s12Yftlu3C_2YbaWgkqhEAe_-gZt-TLuyzSJUyI0RVYHgCPnU55xCtPvUdi79WGD2YM4ezdlizh7MWVMy81PxWHeh-UucVPFfJd1mrg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>216239946</pqid></control><display><type>article</type><title>Histamine H3-receptor isoforms</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Bakker, R A</creator><creatorcontrib>Bakker, R A</creatorcontrib><description>Increasing evidence supports a role for HA as a neurotransmitter and neuromodulator in various brain functions, including emotion, cognition, and feeding. The recent cloning of the histamine H3 receptor allowed for the subsequent cloning of a variety of H3 receptor isoforms from different species as well as the H4 receptor. As a result a wide variety of H3-receptor isoforms are now known that display differential brain expression patterns and signalling properties. These recent discoveries are discussed in view of the growing interest of the H3 receptor as a target for the development of potential therapeutics.</description><identifier>ISSN: 1023-3830</identifier><identifier>EISSN: 1420-908X</identifier><identifier>DOI: 10.1007/s00011-004-1286-9</identifier><identifier>PMID: 15597144</identifier><language>eng</language><publisher>Switzerland: Springer Nature B.V</publisher><subject>Amino Acid Sequence ; Animals ; Brain - metabolism ; Central Nervous System - metabolism ; Histamine Antagonists - pharmacology ; Humans ; Ligands ; Models, Chemical ; Molecular Sequence Data ; Neurotransmitter Agents - metabolism ; Protein Isoforms ; Rats ; Receptors, Histamine H3 - biosynthesis ; Receptors, Histamine H3 - chemistry ; Sequence Homology, Amino Acid ; Signal Transduction ; Tissue Distribution</subject><ispartof>Inflammation research, 2004-10, Vol.53 (10), p.509-516</ispartof><rights>Copyright Springer-Verlag 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c241t-ac452260d2da27d58ee1c7fb5407295d77cbabbd9e1284ffc9fa924582f130183</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15597144$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bakker, R A</creatorcontrib><title>Histamine H3-receptor isoforms</title><title>Inflammation research</title><addtitle>Inflamm Res</addtitle><description>Increasing evidence supports a role for HA as a neurotransmitter and neuromodulator in various brain functions, including emotion, cognition, and feeding. The recent cloning of the histamine H3 receptor allowed for the subsequent cloning of a variety of H3 receptor isoforms from different species as well as the H4 receptor. As a result a wide variety of H3-receptor isoforms are now known that display differential brain expression patterns and signalling properties. These recent discoveries are discussed in view of the growing interest of the H3 receptor as a target for the development of potential therapeutics.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Brain - metabolism</subject><subject>Central Nervous System - metabolism</subject><subject>Histamine Antagonists - pharmacology</subject><subject>Humans</subject><subject>Ligands</subject><subject>Models, Chemical</subject><subject>Molecular Sequence Data</subject><subject>Neurotransmitter Agents - metabolism</subject><subject>Protein Isoforms</subject><subject>Rats</subject><subject>Receptors, Histamine H3 - biosynthesis</subject><subject>Receptors, Histamine H3 - chemistry</subject><subject>Sequence Homology, Amino Acid</subject><subject>Signal Transduction</subject><subject>Tissue Distribution</subject><issn>1023-3830</issn><issn>1420-908X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkMFKAzEURYMotlY_wE0pLtxF816SSbKUolYouFFwFzKZBKZ0OjWZWfj3prQguHpvce7lcgi5BfYAjKnHzBgDoIwJCqgras7IFAQyapj-Oi8_Q0655mxCrnLeFFqjxksyASmNAiGmZL5q8-C6dhcWK05T8GE_9GnR5j72qcvX5CK6bQ43pzsjny_PH8sVXb-_vi2f1tSjgIE6LyRixRpsHKpG6hDAq1hLwRQa2Sjla1fXjQllp4jRm-gMCqkxAmeg-YzcH3v3qf8eQx5s12Yftlu3C_2YbaWgkqhEAe_-gZt-TLuyzSJUyI0RVYHgCPnU55xCtPvUdi79WGD2YM4ezdlizh7MWVMy81PxWHeh-UucVPFfJd1mrg</recordid><startdate>200410</startdate><enddate>200410</enddate><creator>Bakker, R A</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200410</creationdate><title>Histamine H3-receptor isoforms</title><author>Bakker, R A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c241t-ac452260d2da27d58ee1c7fb5407295d77cbabbd9e1284ffc9fa924582f130183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Brain - metabolism</topic><topic>Central Nervous System - metabolism</topic><topic>Histamine Antagonists - pharmacology</topic><topic>Humans</topic><topic>Ligands</topic><topic>Models, Chemical</topic><topic>Molecular Sequence Data</topic><topic>Neurotransmitter Agents - metabolism</topic><topic>Protein Isoforms</topic><topic>Rats</topic><topic>Receptors, Histamine H3 - biosynthesis</topic><topic>Receptors, Histamine H3 - chemistry</topic><topic>Sequence Homology, Amino Acid</topic><topic>Signal Transduction</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bakker, R A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Inflammation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bakker, R A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histamine H3-receptor isoforms</atitle><jtitle>Inflammation research</jtitle><addtitle>Inflamm Res</addtitle><date>2004-10</date><risdate>2004</risdate><volume>53</volume><issue>10</issue><spage>509</spage><epage>516</epage><pages>509-516</pages><issn>1023-3830</issn><eissn>1420-908X</eissn><abstract>Increasing evidence supports a role for HA as a neurotransmitter and neuromodulator in various brain functions, including emotion, cognition, and feeding. The recent cloning of the histamine H3 receptor allowed for the subsequent cloning of a variety of H3 receptor isoforms from different species as well as the H4 receptor. As a result a wide variety of H3-receptor isoforms are now known that display differential brain expression patterns and signalling properties. These recent discoveries are discussed in view of the growing interest of the H3 receptor as a target for the development of potential therapeutics.</abstract><cop>Switzerland</cop><pub>Springer Nature B.V</pub><pmid>15597144</pmid><doi>10.1007/s00011-004-1286-9</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1023-3830 |
| ispartof | Inflammation research, 2004-10, Vol.53 (10), p.509-516 |
| issn | 1023-3830 1420-908X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67165274 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Amino Acid Sequence Animals Brain - metabolism Central Nervous System - metabolism Histamine Antagonists - pharmacology Humans Ligands Models, Chemical Molecular Sequence Data Neurotransmitter Agents - metabolism Protein Isoforms Rats Receptors, Histamine H3 - biosynthesis Receptors, Histamine H3 - chemistry Sequence Homology, Amino Acid Signal Transduction Tissue Distribution |
| title | Histamine H3-receptor isoforms |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T00%3A47%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Histamine%20H3-receptor%20isoforms&rft.jtitle=Inflammation%20research&rft.au=Bakker,%20R%20A&rft.date=2004-10&rft.volume=53&rft.issue=10&rft.spage=509&rft.epage=516&rft.pages=509-516&rft.issn=1023-3830&rft.eissn=1420-908X&rft_id=info:doi/10.1007/s00011-004-1286-9&rft_dat=%3Cproquest_cross%3E765842691%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=216239946&rft_id=info:pmid/15597144&rfr_iscdi=true |