Histamine H3-receptor isoforms

Increasing evidence supports a role for HA as a neurotransmitter and neuromodulator in various brain functions, including emotion, cognition, and feeding. The recent cloning of the histamine H3 receptor allowed for the subsequent cloning of a variety of H3 receptor isoforms from different species as...

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Veröffentlicht in:Inflammation research 2004-10, Vol.53 (10), p.509-516
1. Verfasser: Bakker, R A
Format: Artikel
Sprache:eng
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Zusammenfassung:Increasing evidence supports a role for HA as a neurotransmitter and neuromodulator in various brain functions, including emotion, cognition, and feeding. The recent cloning of the histamine H3 receptor allowed for the subsequent cloning of a variety of H3 receptor isoforms from different species as well as the H4 receptor. As a result a wide variety of H3-receptor isoforms are now known that display differential brain expression patterns and signalling properties. These recent discoveries are discussed in view of the growing interest of the H3 receptor as a target for the development of potential therapeutics.
ISSN:1023-3830
1420-908X
DOI:10.1007/s00011-004-1286-9