Parallel Supported Synthesis of Polyamine−Imidazole Conjugates

Parallel Supported Synthesis of Polyamine−Imidazole Conjugates

A small collection of nine polyamine−imidazole conjugates, potentially acting as RNases A mimics, has been synthesized on SynPhase lanterns using amino alcohols and diamines as building blocks. Couplings were performed via SN2 alkylation of methanesulfonates with amines. The final introduction of N-...

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Veröffentlicht in:Organic letters 2004-12, Vol.6 (25), p.4711-4714
Hauptverfasser: Picard, Sylvie, Le Roch, Myriam, Renault, Jacques, Uriac, Philippe
Format: Artikel
Sprache:eng
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Zusammenfassung:A small collection of nine polyamine−imidazole conjugates, potentially acting as RNases A mimics, has been synthesized on SynPhase lanterns using amino alcohols and diamines as building blocks. Couplings were performed via SN2 alkylation of methanesulfonates with amines. The final introduction of N-4-nitrobenzyloxycarbonyldiamines allowed easy purification of the cleaved compounds.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0480630