Cyclic Sulfamidates as Vehicles for the Synthesis of Substituted Lactams

Cyclic Sulfamidates as Vehicles for the Synthesis of Substituted Lactams

A structurally diverse series of mono- and disubstituted 1,2- and 1,3-cyclic sulfamidates react with stabilized enolates, including malonate and phosphonoacetate variants, to provide, after lactamization, substituted and α-functionalized pyrrolidinone and piperidinone derivatives.

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Veröffentlicht in:Organic letters 2004-12, Vol.6 (25), p.4727-4730
Hauptverfasser: Bower, John F, Švenda, Jakub, Williams, Andrew J, Charmant, Jonathan P. H, Lawrence, Ron M, Szeto, Peter, Gallagher, Timothy
Format: Artikel
Sprache:eng
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Zusammenfassung:A structurally diverse series of mono- and disubstituted 1,2- and 1,3-cyclic sulfamidates react with stabilized enolates, including malonate and phosphonoacetate variants, to provide, after lactamization, substituted and α-functionalized pyrrolidinone and piperidinone derivatives.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol048036+