Circulating endothelial progenitor cells and depression: a possible novel link between heart and soul
Although depression is known to be an independent risk factor for cardiovascular disorders, the mechanisms behind this connection are not well understood. However, the reduction in the number of endothelial progenitor cells (EPCs) in patients with cardiovascular risk factors has led us to hypothesiz...
Gespeichert in:
| Veröffentlicht in: | Molecular psychiatry 2009-05, Vol.14 (5), p.523-531 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 531 |
|---|---|
| container_issue | 5 |
| container_start_page | 523 |
| container_title | Molecular psychiatry |
| container_volume | 14 |
| creator | Dome, P Teleki, Z Rihmer, Z Peter, L Dobos, J Kenessey, I Tovari, J Timar, J Paku, S Kovacs, G Dome, B |
| description | Although depression is known to be an independent risk factor for cardiovascular disorders, the mechanisms behind this connection are not well understood. However, the reduction in the number of endothelial progenitor cells (EPCs) in patients with cardiovascular risk factors has led us to hypothesize that depression influences the number of EPCs. EPCs labeled with CD34, CD133 and vascular endothelial growth factor receptor-2 (VEGFR2) antibodies were counted by flow cytometry in the peripheral blood (PB) of 33 patients with a current episode of major depression and of 16 control subjects. Mature (CD34+/VEGFR2+) and immature (CD133+/VEGFR2+) EPC counts were decreased in patients (vs controls;
P |
| doi_str_mv | 10.1038/sj.mp.4002138 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_67152807</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A198810003</galeid><sourcerecordid>A198810003</sourcerecordid><originalsourceid>FETCH-LOGICAL-c540t-b349b5d360108525454f1fe1d7fce1e1e70c049d43561493148900ce3290d7133</originalsourceid><addsrcrecordid>eNqFkc-L1TAQx4so7rp69CpB0VufM03SpntbHv6CBS96Dmk7fdtnmtSkVfzvTX3FB6JIDhmYT74z33yz7CnCDoGr1_G4G6edACiQq3vZJYqqzKWs1P1Uc1nnApW4yB7FeARYm_JhdoEKFVRSXWa0H0K7WDMP7sDIdX6-IzsYy6bgD-SG2QfWkrWRGdexjqZAMQ7eXTPDJp_KxhJz_htZZgf3hTU0fydy7I5MmH-9iX6xj7MHvbGRnmz3Vfb57ZtP-_f57cd3H_Y3t3krBcx5w0XdyI6XgKBkIYUUPfaEXdW3hOlU0IKoO8FliaLmKFQN0BIvaugq5Pwqe3XSTdt_XSjOehziur5x5JeoywplkZz_FyygRJBlncAXf4BHvwSXTOiiFLIqsVAqUc__SRWIZSFAnKUOxpIeXO_nYNp1rr7BWikEgNVCfqLakL43UK-nMIwm_NAIek1cx6MeJ70lnvhn2-ilGak701vECXi5ASa2xvbBuHaIv7kkIrkQ63q7ExdTyx0onD38ffJPWpDAOw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>221162404</pqid></control><display><type>article</type><title>Circulating endothelial progenitor cells and depression: a possible novel link between heart and soul</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Dome, P ; Teleki, Z ; Rihmer, Z ; Peter, L ; Dobos, J ; Kenessey, I ; Tovari, J ; Timar, J ; Paku, S ; Kovacs, G ; Dome, B</creator><creatorcontrib>Dome, P ; Teleki, Z ; Rihmer, Z ; Peter, L ; Dobos, J ; Kenessey, I ; Tovari, J ; Timar, J ; Paku, S ; Kovacs, G ; Dome, B</creatorcontrib><description>Although depression is known to be an independent risk factor for cardiovascular disorders, the mechanisms behind this connection are not well understood. However, the reduction in the number of endothelial progenitor cells (EPCs) in patients with cardiovascular risk factors has led us to hypothesize that depression influences the number of EPCs. EPCs labeled with CD34, CD133 and vascular endothelial growth factor receptor-2 (VEGFR2) antibodies were counted by flow cytometry in the peripheral blood (PB) of 33 patients with a current episode of major depression and of 16 control subjects. Mature (CD34+/VEGFR2+) and immature (CD133+/VEGFR2+) EPC counts were decreased in patients (vs controls;
P
<0.01 for both comparisons), and there was a significant inverse relationship between EPC levels and the severity of depressive symptoms (
P
<0.01 for both EPC phenotypes). Additionally, we assayed the plasma levels of VEGF, C-reactive protein (CRP) and tumor necrosis factor (TNF)-α and observed significantly elevated TNF-α concentrations in patients (vs controls;
P
<0.05) and, moreover, a significant inverse correlation between TNF-α and EPC levels (
P
<0.05). Moreover, by means of a quantitative RT-PCR approach, we measured CD34, CD133 and VEGFR2 mRNA levels of PB samples and found a net trend toward a decrease in all the investigated EPC-specific mRNA levels in patients as compared with controls. However, statistical significance was reached only for VEGFR2 and CD133 levels (
P
<0.01 for both markers). This is the first paper that demonstrates evidence of decreased numbers of circulating EPCs in patients with a current episode of major depression.</description><identifier>ISSN: 1359-4184</identifier><identifier>EISSN: 1476-5578</identifier><identifier>DOI: 10.1038/sj.mp.4002138</identifier><identifier>PMID: 18180758</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>AC133 Antigen ; Adult ; Adult and adolescent clinical studies ; Analysis of Variance ; Antigens, CD - genetics ; Antigens, CD - metabolism ; Antigens, CD34 - genetics ; Antigens, CD34 - metabolism ; Behavioral Sciences ; Biological and medical sciences ; Biological Psychology ; Bone marrow cells ; C-reactive protein ; C-Reactive Protein - metabolism ; Cardiovascular diseases ; CD34 antigen ; Demographic aspects ; Depression ; Depression, Mental ; Depressive Disorder, Major - blood ; Development and progression ; Endothelial Cells - metabolism ; Endothelial Cells - pathology ; Female ; Flow cytometry ; Flow Cytometry - methods ; Glycoproteins - genetics ; Glycoproteins - metabolism ; Humans ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Mental depression ; Middle Aged ; Mood disorders ; Mortality ; mRNA ; Neurosciences ; original-article ; Peptides - genetics ; Peptides - metabolism ; Peripheral blood ; Pharmacotherapy ; Phenotypes ; Physiological aspects ; Plasma levels ; Polymerase chain reaction ; Progenitor cells ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Risk factors ; RNA, Messenger - metabolism ; Severity of Illness Index ; Statistics as Topic ; Stem cells ; Stem Cells - metabolism ; Stem Cells - pathology ; Tumor Necrosis Factor-alpha - blood ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - blood ; Vascular Endothelial Growth Factor Receptor-2 - genetics ; Vascular Endothelial Growth Factor Receptor-2 - metabolism ; Vascular endothelial growth factor receptors</subject><ispartof>Molecular psychiatry, 2009-05, Vol.14 (5), p.523-531</ispartof><rights>Springer Nature Limited 2009</rights><rights>2009 INIST-CNRS</rights><rights>COPYRIGHT 2009 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group May 2009</rights><rights>Nature Publishing Group 2009.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-b349b5d360108525454f1fe1d7fce1e1e70c049d43561493148900ce3290d7133</citedby><cites>FETCH-LOGICAL-c540t-b349b5d360108525454f1fe1d7fce1e1e70c049d43561493148900ce3290d7133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.mp.4002138$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.mp.4002138$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21353444$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18180758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dome, P</creatorcontrib><creatorcontrib>Teleki, Z</creatorcontrib><creatorcontrib>Rihmer, Z</creatorcontrib><creatorcontrib>Peter, L</creatorcontrib><creatorcontrib>Dobos, J</creatorcontrib><creatorcontrib>Kenessey, I</creatorcontrib><creatorcontrib>Tovari, J</creatorcontrib><creatorcontrib>Timar, J</creatorcontrib><creatorcontrib>Paku, S</creatorcontrib><creatorcontrib>Kovacs, G</creatorcontrib><creatorcontrib>Dome, B</creatorcontrib><title>Circulating endothelial progenitor cells and depression: a possible novel link between heart and soul</title><title>Molecular psychiatry</title><addtitle>Mol Psychiatry</addtitle><addtitle>Mol Psychiatry</addtitle><description>Although depression is known to be an independent risk factor for cardiovascular disorders, the mechanisms behind this connection are not well understood. However, the reduction in the number of endothelial progenitor cells (EPCs) in patients with cardiovascular risk factors has led us to hypothesize that depression influences the number of EPCs. EPCs labeled with CD34, CD133 and vascular endothelial growth factor receptor-2 (VEGFR2) antibodies were counted by flow cytometry in the peripheral blood (PB) of 33 patients with a current episode of major depression and of 16 control subjects. Mature (CD34+/VEGFR2+) and immature (CD133+/VEGFR2+) EPC counts were decreased in patients (vs controls;
P
<0.01 for both comparisons), and there was a significant inverse relationship between EPC levels and the severity of depressive symptoms (
P
<0.01 for both EPC phenotypes). Additionally, we assayed the plasma levels of VEGF, C-reactive protein (CRP) and tumor necrosis factor (TNF)-α and observed significantly elevated TNF-α concentrations in patients (vs controls;
P
<0.05) and, moreover, a significant inverse correlation between TNF-α and EPC levels (
P
<0.05). Moreover, by means of a quantitative RT-PCR approach, we measured CD34, CD133 and VEGFR2 mRNA levels of PB samples and found a net trend toward a decrease in all the investigated EPC-specific mRNA levels in patients as compared with controls. However, statistical significance was reached only for VEGFR2 and CD133 levels (
P
<0.01 for both markers). This is the first paper that demonstrates evidence of decreased numbers of circulating EPCs in patients with a current episode of major depression.</description><subject>AC133 Antigen</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Analysis of Variance</subject><subject>Antigens, CD - genetics</subject><subject>Antigens, CD - metabolism</subject><subject>Antigens, CD34 - genetics</subject><subject>Antigens, CD34 - metabolism</subject><subject>Behavioral Sciences</subject><subject>Biological and medical sciences</subject><subject>Biological Psychology</subject><subject>Bone marrow cells</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiovascular diseases</subject><subject>CD34 antigen</subject><subject>Demographic aspects</subject><subject>Depression</subject><subject>Depression, Mental</subject><subject>Depressive Disorder, Major - blood</subject><subject>Development and progression</subject><subject>Endothelial Cells - metabolism</subject><subject>Endothelial Cells - pathology</subject><subject>Female</subject><subject>Flow cytometry</subject><subject>Flow Cytometry - methods</subject><subject>Glycoproteins - genetics</subject><subject>Glycoproteins - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental depression</subject><subject>Middle Aged</subject><subject>Mood disorders</subject><subject>Mortality</subject><subject>mRNA</subject><subject>Neurosciences</subject><subject>original-article</subject><subject>Peptides - genetics</subject><subject>Peptides - metabolism</subject><subject>Peripheral blood</subject><subject>Pharmacotherapy</subject><subject>Phenotypes</subject><subject>Physiological aspects</subject><subject>Plasma levels</subject><subject>Polymerase chain reaction</subject><subject>Progenitor cells</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Risk factors</subject><subject>RNA, Messenger - metabolism</subject><subject>Severity of Illness Index</subject><subject>Statistics as Topic</subject><subject>Stem cells</subject><subject>Stem Cells - metabolism</subject><subject>Stem Cells - pathology</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis factor-α</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A - blood</subject><subject>Vascular Endothelial Growth Factor Receptor-2 - genetics</subject><subject>Vascular Endothelial Growth Factor Receptor-2 - metabolism</subject><subject>Vascular endothelial growth factor receptors</subject><issn>1359-4184</issn><issn>1476-5578</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkc-L1TAQx4so7rp69CpB0VufM03SpntbHv6CBS96Dmk7fdtnmtSkVfzvTX3FB6JIDhmYT74z33yz7CnCDoGr1_G4G6edACiQq3vZJYqqzKWs1P1Uc1nnApW4yB7FeARYm_JhdoEKFVRSXWa0H0K7WDMP7sDIdX6-IzsYy6bgD-SG2QfWkrWRGdexjqZAMQ7eXTPDJp_KxhJz_htZZgf3hTU0fydy7I5MmH-9iX6xj7MHvbGRnmz3Vfb57ZtP-_f57cd3H_Y3t3krBcx5w0XdyI6XgKBkIYUUPfaEXdW3hOlU0IKoO8FliaLmKFQN0BIvaugq5Pwqe3XSTdt_XSjOehziur5x5JeoywplkZz_FyygRJBlncAXf4BHvwSXTOiiFLIqsVAqUc__SRWIZSFAnKUOxpIeXO_nYNp1rr7BWikEgNVCfqLakL43UK-nMIwm_NAIek1cx6MeJ70lnvhn2-ilGak701vECXi5ASa2xvbBuHaIv7kkIrkQ63q7ExdTyx0onD38ffJPWpDAOw</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>Dome, P</creator><creator>Teleki, Z</creator><creator>Rihmer, Z</creator><creator>Peter, L</creator><creator>Dobos, J</creator><creator>Kenessey, I</creator><creator>Tovari, J</creator><creator>Timar, J</creator><creator>Paku, S</creator><creator>Kovacs, G</creator><creator>Dome, B</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20090501</creationdate><title>Circulating endothelial progenitor cells and depression: a possible novel link between heart and soul</title><author>Dome, P ; Teleki, Z ; Rihmer, Z ; Peter, L ; Dobos, J ; Kenessey, I ; Tovari, J ; Timar, J ; Paku, S ; Kovacs, G ; Dome, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-b349b5d360108525454f1fe1d7fce1e1e70c049d43561493148900ce3290d7133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>AC133 Antigen</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Analysis of Variance</topic><topic>Antigens, CD - genetics</topic><topic>Antigens, CD - metabolism</topic><topic>Antigens, CD34 - genetics</topic><topic>Antigens, CD34 - metabolism</topic><topic>Behavioral Sciences</topic><topic>Biological and medical sciences</topic><topic>Biological Psychology</topic><topic>Bone marrow cells</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cardiovascular diseases</topic><topic>CD34 antigen</topic><topic>Demographic aspects</topic><topic>Depression</topic><topic>Depression, Mental</topic><topic>Depressive Disorder, Major - blood</topic><topic>Development and progression</topic><topic>Endothelial Cells - metabolism</topic><topic>Endothelial Cells - pathology</topic><topic>Female</topic><topic>Flow cytometry</topic><topic>Flow Cytometry - methods</topic><topic>Glycoproteins - genetics</topic><topic>Glycoproteins - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mental depression</topic><topic>Middle Aged</topic><topic>Mood disorders</topic><topic>Mortality</topic><topic>mRNA</topic><topic>Neurosciences</topic><topic>original-article</topic><topic>Peptides - genetics</topic><topic>Peptides - metabolism</topic><topic>Peripheral blood</topic><topic>Pharmacotherapy</topic><topic>Phenotypes</topic><topic>Physiological aspects</topic><topic>Plasma levels</topic><topic>Polymerase chain reaction</topic><topic>Progenitor cells</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Risk factors</topic><topic>RNA, Messenger - metabolism</topic><topic>Severity of Illness Index</topic><topic>Statistics as Topic</topic><topic>Stem cells</topic><topic>Stem Cells - metabolism</topic><topic>Stem Cells - pathology</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><topic>Vascular endothelial growth factor</topic><topic>Vascular Endothelial Growth Factor A - blood</topic><topic>Vascular Endothelial Growth Factor Receptor-2 - genetics</topic><topic>Vascular Endothelial Growth Factor Receptor-2 - metabolism</topic><topic>Vascular endothelial growth factor receptors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dome, P</creatorcontrib><creatorcontrib>Teleki, Z</creatorcontrib><creatorcontrib>Rihmer, Z</creatorcontrib><creatorcontrib>Peter, L</creatorcontrib><creatorcontrib>Dobos, J</creatorcontrib><creatorcontrib>Kenessey, I</creatorcontrib><creatorcontrib>Tovari, J</creatorcontrib><creatorcontrib>Timar, J</creatorcontrib><creatorcontrib>Paku, S</creatorcontrib><creatorcontrib>Kovacs, G</creatorcontrib><creatorcontrib>Dome, B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dome, P</au><au>Teleki, Z</au><au>Rihmer, Z</au><au>Peter, L</au><au>Dobos, J</au><au>Kenessey, I</au><au>Tovari, J</au><au>Timar, J</au><au>Paku, S</au><au>Kovacs, G</au><au>Dome, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating endothelial progenitor cells and depression: a possible novel link between heart and soul</atitle><jtitle>Molecular psychiatry</jtitle><stitle>Mol Psychiatry</stitle><addtitle>Mol Psychiatry</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>14</volume><issue>5</issue><spage>523</spage><epage>531</epage><pages>523-531</pages><issn>1359-4184</issn><eissn>1476-5578</eissn><abstract>Although depression is known to be an independent risk factor for cardiovascular disorders, the mechanisms behind this connection are not well understood. However, the reduction in the number of endothelial progenitor cells (EPCs) in patients with cardiovascular risk factors has led us to hypothesize that depression influences the number of EPCs. EPCs labeled with CD34, CD133 and vascular endothelial growth factor receptor-2 (VEGFR2) antibodies were counted by flow cytometry in the peripheral blood (PB) of 33 patients with a current episode of major depression and of 16 control subjects. Mature (CD34+/VEGFR2+) and immature (CD133+/VEGFR2+) EPC counts were decreased in patients (vs controls;
P
<0.01 for both comparisons), and there was a significant inverse relationship between EPC levels and the severity of depressive symptoms (
P
<0.01 for both EPC phenotypes). Additionally, we assayed the plasma levels of VEGF, C-reactive protein (CRP) and tumor necrosis factor (TNF)-α and observed significantly elevated TNF-α concentrations in patients (vs controls;
P
<0.05) and, moreover, a significant inverse correlation between TNF-α and EPC levels (
P
<0.05). Moreover, by means of a quantitative RT-PCR approach, we measured CD34, CD133 and VEGFR2 mRNA levels of PB samples and found a net trend toward a decrease in all the investigated EPC-specific mRNA levels in patients as compared with controls. However, statistical significance was reached only for VEGFR2 and CD133 levels (
P
<0.01 for both markers). This is the first paper that demonstrates evidence of decreased numbers of circulating EPCs in patients with a current episode of major depression.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>18180758</pmid><doi>10.1038/sj.mp.4002138</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-4184 |
| ispartof | Molecular psychiatry, 2009-05, Vol.14 (5), p.523-531 |
| issn | 1359-4184 1476-5578 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67152807 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | AC133 Antigen Adult Adult and adolescent clinical studies Analysis of Variance Antigens, CD - genetics Antigens, CD - metabolism Antigens, CD34 - genetics Antigens, CD34 - metabolism Behavioral Sciences Biological and medical sciences Biological Psychology Bone marrow cells C-reactive protein C-Reactive Protein - metabolism Cardiovascular diseases CD34 antigen Demographic aspects Depression Depression, Mental Depressive Disorder, Major - blood Development and progression Endothelial Cells - metabolism Endothelial Cells - pathology Female Flow cytometry Flow Cytometry - methods Glycoproteins - genetics Glycoproteins - metabolism Humans Male Medical sciences Medicine Medicine & Public Health Mental depression Middle Aged Mood disorders Mortality mRNA Neurosciences original-article Peptides - genetics Peptides - metabolism Peripheral blood Pharmacotherapy Phenotypes Physiological aspects Plasma levels Polymerase chain reaction Progenitor cells Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Risk factors RNA, Messenger - metabolism Severity of Illness Index Statistics as Topic Stem cells Stem Cells - metabolism Stem Cells - pathology Tumor Necrosis Factor-alpha - blood Tumor necrosis factor-TNF Tumor necrosis factor-α Vascular endothelial growth factor Vascular Endothelial Growth Factor A - blood Vascular Endothelial Growth Factor Receptor-2 - genetics Vascular Endothelial Growth Factor Receptor-2 - metabolism Vascular endothelial growth factor receptors |
| title | Circulating endothelial progenitor cells and depression: a possible novel link between heart and soul |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-18T10%3A02%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Circulating%20endothelial%20progenitor%20cells%20and%20depression:%20a%20possible%20novel%20link%20between%20heart%20and%20soul&rft.jtitle=Molecular%20psychiatry&rft.au=Dome,%20P&rft.date=2009-05-01&rft.volume=14&rft.issue=5&rft.spage=523&rft.epage=531&rft.pages=523-531&rft.issn=1359-4184&rft.eissn=1476-5578&rft_id=info:doi/10.1038/sj.mp.4002138&rft_dat=%3Cgale_proqu%3EA198810003%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=221162404&rft_id=info:pmid/18180758&rft_galeid=A198810003&rfr_iscdi=true |