Circulating endothelial progenitor cells and depression: a possible novel link between heart and soul

Although depression is known to be an independent risk factor for cardiovascular disorders, the mechanisms behind this connection are not well understood. However, the reduction in the number of endothelial progenitor cells (EPCs) in patients with cardiovascular risk factors has led us to hypothesiz...

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Veröffentlicht in:	Molecular psychiatry 2009-05, Vol.14 (5), p.523-531
Hauptverfasser:	Dome, P, Teleki, Z, Rihmer, Z, Peter, L, Dobos, J, Kenessey, I, Tovari, J, Timar, J, Paku, S, Kovacs, G, Dome, B
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 Antigen Adult Adult and adolescent clinical studies Analysis of Variance Antigens, CD - genetics Antigens, CD - metabolism Antigens, CD34 - genetics Antigens, CD34 - metabolism Behavioral Sciences Biological and medical sciences Biological Psychology Bone marrow cells C-reactive protein C-Reactive Protein - metabolism Cardiovascular diseases CD34 antigen Demographic aspects Depression Depression, Mental Depressive Disorder, Major - blood Development and progression Endothelial Cells - metabolism Endothelial Cells - pathology Female Flow cytometry Flow Cytometry - methods Glycoproteins - genetics Glycoproteins - metabolism Humans Male Medical sciences Medicine Medicine & Public Health Mental depression Middle Aged Mood disorders Mortality mRNA Neurosciences original-article Peptides - genetics Peptides - metabolism Peripheral blood Pharmacotherapy Phenotypes Physiological aspects Plasma levels Polymerase chain reaction Progenitor cells Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Risk factors RNA, Messenger - metabolism Severity of Illness Index Statistics as Topic Stem cells Stem Cells - metabolism Stem Cells - pathology Tumor Necrosis Factor-alpha - blood Tumor necrosis factor-TNF Tumor necrosis factor-α Vascular endothelial growth factor Vascular Endothelial Growth Factor A - blood Vascular Endothelial Growth Factor Receptor-2 - genetics Vascular Endothelial Growth Factor Receptor-2 - metabolism Vascular endothelial growth factor receptors
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Zusammenfassung:	Although depression is known to be an independent risk factor for cardiovascular disorders, the mechanisms behind this connection are not well understood. However, the reduction in the number of endothelial progenitor cells (EPCs) in patients with cardiovascular risk factors has led us to hypothesize that depression influences the number of EPCs. EPCs labeled with CD34, CD133 and vascular endothelial growth factor receptor-2 (VEGFR2) antibodies were counted by flow cytometry in the peripheral blood (PB) of 33 patients with a current episode of major depression and of 16 control subjects. Mature (CD34+/VEGFR2+) and immature (CD133+/VEGFR2+) EPC counts were decreased in patients (vs controls; P
ISSN:	1359-4184 1476-5578
DOI:	10.1038/sj.mp.4002138