Azido Sialic Acids Can Modulate Cell-Surface Interactions

Delivery of unnatural sialic acids to cell‐surface glycans can alter cellular recognition by sialic acid‐binding proteins. The approach can be used to probe structure–activity relationships in the physiologically relevant context of the cell surface.

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Bibliographische Detailangaben
Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2004-12, Vol.5 (12), p.1706-1709
Hauptverfasser:	Luchansky, Sarah J, Bertozzi, Carolyn R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Azides - chemistry Azides - metabolism carbohydrates Cell Membrane - chemistry Cells, Cultured E-Selectin - chemistry E-Selectin - metabolism Fucosyltransferases - chemistry Fucosyltransferases - metabolism Hexosamines - chemistry Hexosamines - metabolism Humans Immunoglobulin M - immunology Immunoglobulin M - metabolism Lectins - chemistry Lectins - metabolism Ligands Membrane Glycoproteins - chemistry Membrane Glycoproteins - metabolism Oligosaccharides - immunology Oligosaccharides - metabolism Rats Receptors, Immunologic - chemistry Receptors, Immunologic - metabolism selectin Sialic Acid Binding Ig-like Lectin 1 sialic acids Sialic Acids - chemistry Sialic Acids - physiology Sialyltransferases - chemistry Sialyltransferases - metabolism Siglec Staudinger ligation
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Beschreibung
Zusammenfassung:	Delivery of unnatural sialic acids to cell‐surface glycans can alter cellular recognition by sialic acid‐binding proteins. The approach can be used to probe structure–activity relationships in the physiologically relevant context of the cell surface.
ISSN:	1439-4227 1439-7633
DOI:	10.1002/cbic.200400148