Complete Chiral Resolution Using Additive-Induced Crystal Size Bifurcation During Grinding
Grinding them down: By using a tailor-made additive, even in the absence of racemization in solution, abrasive grinding can yield an enantiopure solid state. This novel chiral resolution technique is based on an asymmetric bifurcation in the crystal size distribution as a result of stereoselective h...
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| Veröffentlicht in: | Angewandte Chemie (International ed.) 2009-01, Vol.48 (18), p.3278-3280 |
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| container_end_page | 3280 |
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| container_issue | 18 |
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| container_title | Angewandte Chemie (International ed.) |
| container_volume | 48 |
| creator | Noorduin, Wim L van der Asdonk, Pim Meekes, Hugo van Enckevort, Willem J.P Kaptein, Bernard Leeman, Michel Kellogg, Richard M Vlieg, Elias |
| description | Grinding them down: By using a tailor-made additive, even in the absence of racemization in solution, abrasive grinding can yield an enantiopure solid state. This novel chiral resolution technique is based on an asymmetric bifurcation in the crystal size distribution as a result of stereoselective hampered crystal growth. R=o-tolyl. |
| doi_str_mv | 10.1002/anie.200806214 |
| format | Article |
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This novel chiral resolution technique is based on an asymmetric bifurcation in the crystal size distribution as a result of stereoselective hampered crystal growth. 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| identifier | ISSN: 1433-7851 |
| ispartof | Angewandte Chemie (International ed.), 2009-01, Vol.48 (18), p.3278-3280 |
| issn | 1433-7851 1521-3773 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | amino acids chiral resolution chirality crystal engineering Crystallization - methods grinding Stereoisomerism |
| title | Complete Chiral Resolution Using Additive-Induced Crystal Size Bifurcation During Grinding |
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