Complete Chiral Resolution Using Additive-Induced Crystal Size Bifurcation During Grinding

Complete Chiral Resolution Using Additive-Induced Crystal Size Bifurcation During Grinding

Grinding them down: By using a tailor-made additive, even in the absence of racemization in solution, abrasive grinding can yield an enantiopure solid state. This novel chiral resolution technique is based on an asymmetric bifurcation in the crystal size distribution as a result of stereoselective h...

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Veröffentlicht in:Angewandte Chemie (International ed.) 2009-01, Vol.48 (18), p.3278-3280
Hauptverfasser: Noorduin, Wim L, van der Asdonk, Pim, Meekes, Hugo, van Enckevort, Willem J.P, Kaptein, Bernard, Leeman, Michel, Kellogg, Richard M, Vlieg, Elias
Format: Artikel
Sprache:eng
Schlagworte:
amino acids
chiral resolution
chirality
crystal engineering
Crystallization - methods
grinding
Stereoisomerism
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Zusammenfassung:Grinding them down: By using a tailor-made additive, even in the absence of racemization in solution, abrasive grinding can yield an enantiopure solid state. This novel chiral resolution technique is based on an asymmetric bifurcation in the crystal size distribution as a result of stereoselective hampered crystal growth. R=o-tolyl.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200806214