Mannan-binding lectin-associated serine protease-2 (MASP-2) in a large cohort of neonates and its clinical associations

One collectin (mannan-binding lectin, MBL) and three ficolins (M-ficolin/ficolin-1, L-ficolin/ficolin-2 and H-ficolin/ficolin-3) share the capability to activate complement via the lectin pathway. This property depends on the ability of these lectins to form complexes with MBL-associated serine prot...

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Veröffentlicht in:	Molecular immunology 2009-05, Vol.46 (8), p.1696-1701
Hauptverfasser:	Swierzko, Anna St, Cedzynski, Maciej, Domzalska-Popadiuk, Iwona, MacDonald, Shirley L., Borkowska-Klos, Monika, Atkinson, Anne P.M., Szala, Agnieszka, Jopek, Aleksandra, Jensenius, Jens C., Kawakami, Masaya, Szczapa, Jerzy, Matsushita, Misao, Szemraj, Janusz, Turner, Marc L., Kilpatrick, David C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Birth Weight - physiology Cohort Studies Female Fetal Blood - chemistry Fetal Blood - metabolism Genetic Predisposition to Disease Genotype Gestational Age Humans Infant, Low Birth Weight - blood Infant, Low Birth Weight - metabolism Infant, Newborn Infant, Newborn, Diseases - blood Infant, Newborn, Diseases - genetics Infant, Newborn, Diseases - metabolism Infection - blood Infection - genetics Infection - metabolism Innate immunity Lectin pathway of complement Male Mannose-Binding Protein-Associated Serine Proteases - analysis Mannose-Binding Protein-Associated Serine Proteases - genetics Mannose-Binding Protein-Associated Serine Proteases - metabolism MASP-2 Neonate Polymorphism, Single Nucleotide - physiology Premature Birth - blood Premature Birth - genetics Premature Birth - metabolism
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Zusammenfassung:	One collectin (mannan-binding lectin, MBL) and three ficolins (M-ficolin/ficolin-1, L-ficolin/ficolin-2 and H-ficolin/ficolin-3) share the capability to activate complement via the lectin pathway. This property depends on the ability of these lectins to form complexes with MBL-associated serine proteases (MASPs), particularly MASP-2. We report the results of an investigation of cord blood MASP-2 concentrations in a large, ethnically homogeneous cohort ( n = 1788) of neonates. The median value of MASP-2 in cord sera was determined to be 93 ng/ml (range
ISSN:	0161-5890 1872-9142
DOI:	10.1016/j.molimm.2009.02.022