Synthesis and antifungal activity of cholesterol-hydrazone derivatives

A series of hydrazones synthesized from various cholesterol derivatives were evaluated for their in vitro antimicrobial properties against human pathogens. The activity was highly dependent on the structure of the different compounds involved. The best results have been obtained with tosylhydrazone...

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Veröffentlicht in:	European journal of medicinal chemistry 2004-12, Vol.39 (12), p.1067-1071
Hauptverfasser:	Loncle, Céline, Brunel, Jean Michel, Vidal, Nicolas, Dherbomez, Michel, Letourneux, Yves
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal activity Antifungal agents Antifungal Agents - chemical synthesis Antifungal Agents - pharmacology Antimicrobial activity Biological and medical sciences Cholesterol - analogs & derivatives Cholesterol - chemical synthesis Cholesterol - pharmacology Cholesterol derivatives Hydrazone Hydrazones - chemical synthesis Hydrazones - pharmacology Medical sciences Pharmacology. Drug treatments
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Beschreibung
Zusammenfassung:	A series of hydrazones synthesized from various cholesterol derivatives were evaluated for their in vitro antimicrobial properties against human pathogens. The activity was highly dependent on the structure of the different compounds involved. The best results have been obtained with tosylhydrazone cholesterol derivatives 8 and 9 exhibiting activities against Candida albicans (CIP 1663-80) at a concentration of 1.5 μg/ml.
ISSN:	0223-5234 1768-3254
DOI:	10.1016/j.ejmech.2004.07.005