A Novel Use for Drotrecogin Alfa (Activated): Successful Treatment of Septic Shock Associated with Coccidioidomycosis

We present 2 cases of septic shock associated with coccidioidomycosis that were successfully treated with drotrecogin alfa (activated) in combination with antifungal agents. The favorable outcomes, in light of the high mortality usually associated with this condition, suggest that drotrecogin alfa (...

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Veröffentlicht in:	Clinical infectious diseases 2004-12, Vol.39 (11), p.e122-e123
Hauptverfasser:	Crum, Nancy F., Groff, Harold L., Parrish, John S., Ring, William
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anti-Infective Agents - therapeutic use Coccidioidomycosis - complications Coccidioidomycosis - drug therapy Humans Male Middle Aged Protein C - therapeutic use Recombinant Proteins - therapeutic use Remission Induction Shock, Septic - drug therapy Shock, Septic - etiology
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Zusammenfassung:	We present 2 cases of septic shock associated with coccidioidomycosis that were successfully treated with drotrecogin alfa (activated) in combination with antifungal agents. The favorable outcomes, in light of the high mortality usually associated with this condition, suggest that drotrecogin alfa (activated) may be a valuable adjunct for treating septic shock due to endemic mycoses.
ISSN:	1058-4838 1537-6591
DOI:	10.1086/425918