Stability of two new anticonvulsants in body fluids and tissues
Stability of two compounds with established anticonvulsant activity, picolinic acid benzylamide (Pic-BZA) and nicotinic acid benzylamide (Nic-BZA), incubated in homogenates of body organs and in body fluids was determined at different time points. Pic-BZA was found to decompose fairly rapidly in the...
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Veröffentlicht in: | Acta Poloniae pharmaceutica 2004-07, Vol.61 (4), p.263-266 |
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description | Stability of two compounds with established anticonvulsant activity, picolinic acid benzylamide (Pic-BZA) and nicotinic acid benzylamide (Nic-BZA), incubated in homogenates of body organs and in body fluids was determined at different time points. Pic-BZA was found to decompose fairly rapidly in the liver and the kidney, while Nic-BZA demonstrated stability against enzymes present in these organs and fluids. |
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Pic-BZA was found to decompose fairly rapidly in the liver and the kidney, while Nic-BZA demonstrated stability against enzymes present in these organs and fluids.</description><identifier>ISSN: 0001-6837</identifier><identifier>PMID: 15575592</identifier><language>eng</language><publisher>Poland</publisher><subject>Animals ; Anticonvulsants - isolation & purification ; Anticonvulsants - pharmacokinetics ; Anticonvulsants - pharmacology ; Benzyl Compounds - isolation & purification ; Benzyl Compounds - pharmacokinetics ; Benzyl Compounds - pharmacology ; Body Fluids - chemistry ; Body Fluids - metabolism ; Brain Chemistry ; Chromatography, High Pressure Liquid ; Drug Stability ; Kidney - chemistry ; Kidney - metabolism ; Liver - chemistry ; Liver - metabolism ; Lung - metabolism ; Niacin - analogs & derivatives ; Niacin - isolation & purification ; Niacin - pharmacokinetics ; Niacin - pharmacology ; Picolinic Acids - isolation & purification ; Picolinic Acids - pharmacokinetics ; Picolinic Acids - pharmacology ; Rats ; Time Factors</subject><ispartof>Acta Poloniae pharmaceutica, 2004-07, Vol.61 (4), p.263-266</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15575592$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goldnik, Anna</creatorcontrib><creatorcontrib>Marszałek, Dorota</creatorcontrib><creatorcontrib>Paruszewski, Ryszard</creatorcontrib><creatorcontrib>Stables, James P</creatorcontrib><title>Stability of two new anticonvulsants in body fluids and tissues</title><title>Acta Poloniae pharmaceutica</title><addtitle>Acta Pol Pharm</addtitle><description>Stability of two compounds with established anticonvulsant activity, picolinic acid benzylamide (Pic-BZA) and nicotinic acid benzylamide (Nic-BZA), incubated in homogenates of body organs and in body fluids was determined at different time points. Pic-BZA was found to decompose fairly rapidly in the liver and the kidney, while Nic-BZA demonstrated stability against enzymes present in these organs and fluids.</description><subject>Animals</subject><subject>Anticonvulsants - isolation & purification</subject><subject>Anticonvulsants - pharmacokinetics</subject><subject>Anticonvulsants - pharmacology</subject><subject>Benzyl Compounds - isolation & purification</subject><subject>Benzyl Compounds - pharmacokinetics</subject><subject>Benzyl Compounds - pharmacology</subject><subject>Body Fluids - chemistry</subject><subject>Body Fluids - metabolism</subject><subject>Brain Chemistry</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Drug Stability</subject><subject>Kidney - chemistry</subject><subject>Kidney - metabolism</subject><subject>Liver - chemistry</subject><subject>Liver - metabolism</subject><subject>Lung - metabolism</subject><subject>Niacin - analogs & derivatives</subject><subject>Niacin - isolation & purification</subject><subject>Niacin - pharmacokinetics</subject><subject>Niacin - pharmacology</subject><subject>Picolinic Acids - isolation & purification</subject><subject>Picolinic Acids - pharmacokinetics</subject><subject>Picolinic Acids - pharmacology</subject><subject>Rats</subject><subject>Time Factors</subject><issn>0001-6837</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1T0tLxDAYzEFxl3X_guTkrZAvj7bfSWTxBQt7UM8lbROIpE1tEpf-ewuup5lhhhnmimwZY1CUtag2ZB_j1yqZkhUC3JANKFUphXxLHt6Tbp13aaHB0nQOdDRnqsfkujD-ZB9XGqkbaRv6hVqfXR9Xu6fJxZhNvCXXVvto9hfckc_np4_Da3E8vbwdHo_FBFymQgtAFEyjrDvVAWdM2tYyUQKC1aI0EivO0PYoOWgta2VVZ7iUWHKmsBY7cv_XO83he91NzeBiZ7zXowk5NmUFAhmoNXh3CeZ2MH0zzW7Q89L8Xxa_mRRQ0A</recordid><startdate>200407</startdate><enddate>200407</enddate><creator>Goldnik, Anna</creator><creator>Marszałek, Dorota</creator><creator>Paruszewski, Ryszard</creator><creator>Stables, James P</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200407</creationdate><title>Stability of two new anticonvulsants in body fluids and tissues</title><author>Goldnik, Anna ; 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subjects | Animals Anticonvulsants - isolation & purification Anticonvulsants - pharmacokinetics Anticonvulsants - pharmacology Benzyl Compounds - isolation & purification Benzyl Compounds - pharmacokinetics Benzyl Compounds - pharmacology Body Fluids - chemistry Body Fluids - metabolism Brain Chemistry Chromatography, High Pressure Liquid Drug Stability Kidney - chemistry Kidney - metabolism Liver - chemistry Liver - metabolism Lung - metabolism Niacin - analogs & derivatives Niacin - isolation & purification Niacin - pharmacokinetics Niacin - pharmacology Picolinic Acids - isolation & purification Picolinic Acids - pharmacokinetics Picolinic Acids - pharmacology Rats Time Factors |
title | Stability of two new anticonvulsants in body fluids and tissues |
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