Stability of two new anticonvulsants in body fluids and tissues

Stability of two compounds with established anticonvulsant activity, picolinic acid benzylamide (Pic-BZA) and nicotinic acid benzylamide (Nic-BZA), incubated in homogenates of body organs and in body fluids was determined at different time points. Pic-BZA was found to decompose fairly rapidly in the...

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Veröffentlicht in:	Acta Poloniae pharmaceutica 2004-07, Vol.61 (4), p.263-266
Hauptverfasser:	Goldnik, Anna, Marszałek, Dorota, Paruszewski, Ryszard, Stables, James P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants - isolation & purification Anticonvulsants - pharmacokinetics Anticonvulsants - pharmacology Benzyl Compounds - isolation & purification Benzyl Compounds - pharmacokinetics Benzyl Compounds - pharmacology Body Fluids - chemistry Body Fluids - metabolism Brain Chemistry Chromatography, High Pressure Liquid Drug Stability Kidney - chemistry Kidney - metabolism Liver - chemistry Liver - metabolism Lung - metabolism Niacin - analogs & derivatives Niacin - isolation & purification Niacin - pharmacokinetics Niacin - pharmacology Picolinic Acids - isolation & purification Picolinic Acids - pharmacokinetics Picolinic Acids - pharmacology Rats Time Factors
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Zusammenfassung:	Stability of two compounds with established anticonvulsant activity, picolinic acid benzylamide (Pic-BZA) and nicotinic acid benzylamide (Nic-BZA), incubated in homogenates of body organs and in body fluids was determined at different time points. Pic-BZA was found to decompose fairly rapidly in the liver and the kidney, while Nic-BZA demonstrated stability against enzymes present in these organs and fluids.
ISSN:	0001-6837