Acoustic Tonometry: Feasibility Study of a New Principle of Intraocular Pressure Measurement

PURPOSEAn accurate measurement of intraocular pressure (IOP) is still essential for detecting, following-up, and treating glaucoma. The objective of the interdisciplinary project GlauPhon was to prove a new noncontact tonometry principle that analyzes the acoustic oscillation of the eye. METHODThree enucleated porcine eyes were infused via the optic nerve with a saline solution. The IOP was adjusted by varying the height of the infusion bottle. A speaker closed one end of a cylindrical pressure chamber and an eye was fixed to the other side. A PC sound card induced the speaker to oscillate by generating a rectangular signal (20 Hz). A pressure sensor recorded the oscillating pressure within the chamber. For each IOP a calculation was performed that characterizes the attenuation profile. RESULTSEach series of measurements revealed an evident dependency between the amplitude difference and the IOP. The highest signal belonged to low IOP levels and it decreased with increasing IOP. The correlation of the mean acoustical signal with the given IOP showed a highly significant correlation coefficient (r=−0.98). As a result, the measured oscillation parameters are strongly dependent on the exerted IOPs. CONCLUSIONSThe experiments verified the presumed relation between the acoustic oscillation of the eye and the IOP. Nevertheless, further developments are necessary for converting the oscillation parameters into reliable IOP values, to construct a tonometry device for clinical trials.