Solid-Phase Synthesis of Styryl Dyes and their Application as Amyloid Sensors

Solid-Phase Synthesis of Styryl Dyes and their Application as Amyloid Sensors

The combinatorial approach: A library of fluorescent styryl dyes (320 compounds) was prepared by solid‐phase chemistry. The dyes were screened for their detection of amyloid aggregates, which are associated with diseases such as Alzheimer's, and two of the 320 compounds screened, 2C40 and 2E10,...

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Veröffentlicht in:Angewandte Chemie International Edition 2004-11, Vol.43 (46), p.6331-6335
Hauptverfasser: Li, Qian, Lee, Jun-Seok, Ha, Chanki, Park, Chan Beum, Yang, Guang, Gan, Wen Biao, Chang, Young-Tae
Format: Artikel
Sprache:eng
Schlagworte:
Amyloid - analysis
Amyloid - chemistry
Animals
Biosensing Techniques - instrumentation
Biosensing Techniques - methods
Brain - cytology
Brain - metabolism
Color
Coloring Agents - analysis
Coloring Agents - chemical synthesis
Coloring Agents - chemistry
combinatorial chemistry
dyes/pigments
fluorescent probes
imaging agents
Mice
Microscopy, Confocal
Molecular Structure
solid-phase synthesis
Spectrometry, Fluorescence
Styrene - chemistry
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Zusammenfassung:The combinatorial approach: A library of fluorescent styryl dyes (320 compounds) was prepared by solid‐phase chemistry. The dyes were screened for their detection of amyloid aggregates, which are associated with diseases such as Alzheimer's, and two of the 320 compounds screened, 2C40 and 2E10, showed promise as brain‐imaging agents (see microscopy image).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200461600