New sesquiterpenes from Pluchea arabica

Two new sesquiterpenes, godotol A (1) and godotol B (2), were isolated from Pluchea arabica. Their structures were determined by analysis of NMR data. The absolute configurations of 1 and 2 were established by Mosher ester methodology. The godotols displayed weak activity against bacteria and the br...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2004-11, Vol.67 (11), p.1925-1928
Hauptverfasser:	Fatope, M.O, Nair, R.S, Marwah, R.G, Al-Nadhiri, H.H.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Artemia - drug effects Asteraceae - chemistry Biological and medical sciences Biphenyl Compounds Candida albicans - drug effects Escherichia coli - drug effects General pharmacology Klebsiella pneumoniae - drug effects Medical sciences Microbial Sensitivity Tests Molecular Structure Nuclear Magnetic Resonance, Biomolecular Oman Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Picrates - pharmacology Plants, Medicinal - chemistry Pseudomonas aeruginosa - drug effects Salmonella arizonae - drug effects Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology Staphylococcus aureus - drug effects
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Zusammenfassung:	Two new sesquiterpenes, godotol A (1) and godotol B (2), were isolated from Pluchea arabica. Their structures were determined by analysis of NMR data. The absolute configurations of 1 and 2 were established by Mosher ester methodology. The godotols displayed weak activity against bacteria and the brine shrimp larvae. They were also inactive in the DPPH antioxidant assay.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np040054c