Kinesin Family Member 6 Variant Trp719Arg Does Not Associate With Angiographically Defined Coronary Artery Disease in the Ottawa Heart Genomics Study

[...]recent genome-wide association studies for CAD (1) or MI (71% MI in the WTCCC [Wellcome Trust Case Control Consortium] study and 100% MI in the GMIF [German Myocardial Infarction in Families] study) (2) did not report this association. Since the rs20455 SNP is present on the Affymetrix (Santa Clara, California) 500K and the 6.0 single nucleotide polymorphism (SNP) microarrays, we used data from the ongoing OHGS (Ottawa Heart Genomics Study) and the WTCCC study to test whether rs20455 associates with CAD. If we perform the analysis excluding MI, the KIF6 variant shows no association with revascularization or cardiovascular death. [...]the association with the composite end point is apparently driven by MI.