Isolation of Cytochrome P450 Inhibitors from Strawberry Fruit, Fragaria ananassa
A new glycoside, 2-β-d-glucopyranosyloxy-4,6-dihydroxyisovalerophenone (3), was isolated from strawberry fruit along with kaempferol-3-β-d-(6-O-trans-p-coumaroyl)glucopyranoside (1) and kaempferol-3-β-d-(6-O-cis-p-coumaroyl)glucopyranoside (2). Compounds 1 and 2 inhibited activity of a drug-metaboli...
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Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2004-11, Vol.67 (11), p.1839-1841 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | A new glycoside, 2-β-d-glucopyranosyloxy-4,6-dihydroxyisovalerophenone (3), was isolated from strawberry fruit along with kaempferol-3-β-d-(6-O-trans-p-coumaroyl)glucopyranoside (1) and kaempferol-3-β-d-(6-O-cis-p-coumaroyl)glucopyranoside (2). Compounds 1 and 2 inhibited activity of a drug-metabolizing enzyme, CYP3A4. |
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ISSN: | 0163-3864 1520-6025 |
DOI: | 10.1021/np0400104 |