Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial

Summary Background Statins lower high-sensitivity C-reactive protein (hsCRP) and cholesterol concentrations, and hypothesis generating analyses suggest that clinical outcomes improve in patients given statins who achieve hsCRP concentrations less than 2 mg/L in addition to LDL cholesterol less than...

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Veröffentlicht in:	The Lancet (British edition) 2009-04, Vol.373 (9670), p.1175-1182
Hauptverfasser:	Ridker, Paul M, Prof, Dr, Danielson, Eleanor, MIA, Fonseca, Francisco AH, MD, Genest, Jacques, Prof, Gotto, Antonio M, Prof, Kastelein, John JP, Prof, Koenig, Wolfgang, Prof, Libby, Peter, Prof, Lorenzatti, Alberto J, Prof, MacFadyen, Jean G, BA, Nordestgaard, Børge G, Prof, Shepherd, James, Prof, Willerson, James T, Prof, Glynn, Robert J, ScD
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over C-Reactive Protein - drug effects C-Reactive Protein - metabolism Cardiovascular disease Cardiovascular Diseases - epidemiology Cardiovascular Diseases - metabolism Cardiovascular Diseases - prevention & control Cholesterol Cholesterol, LDL - blood Cholesterol, LDL - drug effects Clinical outcomes Data collection Disease-Free Survival Double-Blind Method Female Fluorobenzenes - pharmacology Fluorobenzenes - therapeutic use Heart attacks Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Incidence Internal Medicine Male Middle Aged Myocardial infarction Prophylaxis Proportional Hazards Models Prospective Studies Pyrimidines - pharmacology Pyrimidines - therapeutic use Rosuvastatin Calcium Sensitivity and Specificity Statins Statistics, Nonparametric Studies Sulfonamides - pharmacology Sulfonamides - therapeutic use Treatment Outcome
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Zusammenfassung:	Summary Background Statins lower high-sensitivity C-reactive protein (hsCRP) and cholesterol concentrations, and hypothesis generating analyses suggest that clinical outcomes improve in patients given statins who achieve hsCRP concentrations less than 2 mg/L in addition to LDL cholesterol less than 1·8 mmol/L (
ISSN:	0140-6736 1474-547X
DOI:	10.1016/S0140-6736(09)60447-5