Evaluation of three commercial latex agglutination kits and a commercial enzyme immunoassay for the detection of cryptococcal antigen

We compared the performance of the Meridian CALAS, Wampole Crypto-LA, Murex Cryptococcus latex agglutination assay, and the Meridian Premier EIA for the detection of cryptococcal antigen in serum and CSF. The assays demonstrated similar performance characteristics based on concordance values ≥ 93% b...

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Veröffentlicht in:	Medical mycology (Oxford) 2009-01, Vol.47 (3), p.336-338
Hauptverfasser:	Babady, Ngolela Esther, Bestrom, Jean E., Jespersen, Deborah J., Jones, Mary F., Beito, Elaine M., Binnicker, Matthew J., Wengenack, Nancy L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Fungal - analysis Clinical Laboratory Techniques - methods Cryptococcosis - diagnosis Immunoenzyme Techniques - methods Latex Fixation Tests - methods Reagent Kits, Diagnostic Sensitivity and Specificity Serum - chemistry Serum - microbiology
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Zusammenfassung:	We compared the performance of the Meridian CALAS, Wampole Crypto-LA, Murex Cryptococcus latex agglutination assay, and the Meridian Premier EIA for the detection of cryptococcal antigen in serum and CSF. The assays demonstrated similar performance characteristics based on concordance values ≥ 93% but important differences were noted in endpoint titers.
ISSN:	1369-3786 1460-2709
DOI:	10.1080/13693780802607400