Ganoderic acid DM: Anti-androgenic osteoclastogenesis inhibitor

Prostate cancer is the most common cancer in men in Western countries, with a high incidence of bone metastasis. Ganoderic acid DM, with 5α-reductase inhibitory and androgen receptor (AR) binding activity, isolated from the ethanol extracts of Ganoderma lucidum, can inhibit prostate cancer cell grow...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2009-04, Vol.19 (8), p.2154-2157
Hauptverfasser:	Liu, Jie, Shiono, Jun, Shimizu, Kuniyoshi, Kukita, Akiko, Kukita, Toshio, Kondo, Ryuichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen Antagonists - chemistry Androgen Antagonists - isolation & purification Androgen Antagonists - pharmacology Androgen receptor Animals Anti-androgen activities Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Biological and medical sciences Cell Differentiation - drug effects Cell Line, Tumor Cell Proliferation - drug effects Ganoderic acid DM Ganoderma lucidum General pharmacology Growth Inhibitors - chemistry Growth Inhibitors - isolation & purification Growth Inhibitors - pharmacology Humans Male Medical sciences Mice Osteoclast Osteoclasts - cytology Osteoclasts - drug effects Osteoclasts - physiology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Prostate cancer Rats Reishi Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology
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Zusammenfassung:	Prostate cancer is the most common cancer in men in Western countries, with a high incidence of bone metastasis. Ganoderic acid DM, with 5α-reductase inhibitory and androgen receptor (AR) binding activity, isolated from the ethanol extracts of Ganoderma lucidum, can inhibit prostate cancer cell growth and block osteoclastogenesis.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2009.02.119