Hypoxia-inducible factor in cancer angiogenesis: Structure, regulation and clinical perspectives
Abstract Tumor hypoxia is a common feature of many cancers. A master regulator of hypoxic response is the transcription factor hypoxia-inducible factor-1 (HIF-1). It functions as a master regulator of oxygen and undergoes conformational changes in response to varying oxygen concentrations. In this p...
Gespeichert in:
| Veröffentlicht in: | Critical reviews in oncology/hematology 2009-05, Vol.70 (2), p.93-102 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 102 |
|---|---|
| container_issue | 2 |
| container_start_page | 93 |
| container_title | Critical reviews in oncology/hematology |
| container_volume | 70 |
| creator | Otrock, Zaher K Hatoum, Hassan A Awada, Ahmad H Ishak, Rim S Shamseddine, Ali I |
| description | Abstract Tumor hypoxia is a common feature of many cancers. A master regulator of hypoxic response is the transcription factor hypoxia-inducible factor-1 (HIF-1). It functions as a master regulator of oxygen and undergoes conformational changes in response to varying oxygen concentrations. In this paper, we review what has been described about HIF-1: its structure, its regulation and target genes, its role in cancer, and its implication for cancer therapy. |
| doi_str_mv | 10.1016/j.critrevonc.2009.01.001 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67110872</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1040842809000031</els_id><sourcerecordid>67110872</sourcerecordid><originalsourceid>FETCH-LOGICAL-c523t-386f46e4c713ab1a6b80ab794df80348943631b01c5765f3133fac55ad113bb63</originalsourceid><addsrcrecordid>eNqNksFu1DAQhiMEoqXlFVAucCLpTOw4DgckqIBWqsSh5WwcZ7LykrWDnazYt8fRLlTixMk-fDP-9fnPshyhREBxtS1NsHOgvXemrADaErAEwCfZOcqmLYALfJruwKGQvJJn2YsYtwDAuWieZ2fYohTQVOfZ95vD5H9ZXVjXL8Z2I-WDNrMPuXW50c5QyLXbWL8hR9HGd_n9HBYzL4He5oE2y6hn611i-tyM1lmjx3yiECcys91TvMyeDXqM9PJ0XmTfPn96uL4p7r5-ub3-cFeYumJzwaQYuCBuGmS6Qy06CbprWt4PEhiXLWeCYQdo6kbUA0PGUs661j0i6zrBLrI3x71T8D8XirPa2WhoHLUjv0QlGkSQTZVAeQRN8DEGGtQU7E6Hg0JQq121VY921WpXAapkN42-Or2xdDvqHwdPOhPw-gTomEQMIQm08S9XIWtRtGvYj0eOkpG9paCisZRk9zYkb6r39n_SvP9nyZ8P-EEHilu_BJeMK1SxUqDu1zasZYA2FQGSwd-BErNn</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67110872</pqid></control><display><type>article</type><title>Hypoxia-inducible factor in cancer angiogenesis: Structure, regulation and clinical perspectives</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Otrock, Zaher K ; Hatoum, Hassan A ; Awada, Ahmad H ; Ishak, Rim S ; Shamseddine, Ali I</creator><creatorcontrib>Otrock, Zaher K ; Hatoum, Hassan A ; Awada, Ahmad H ; Ishak, Rim S ; Shamseddine, Ali I</creatorcontrib><description>Abstract Tumor hypoxia is a common feature of many cancers. A master regulator of hypoxic response is the transcription factor hypoxia-inducible factor-1 (HIF-1). It functions as a master regulator of oxygen and undergoes conformational changes in response to varying oxygen concentrations. In this paper, we review what has been described about HIF-1: its structure, its regulation and target genes, its role in cancer, and its implication for cancer therapy.</description><identifier>ISSN: 1040-8428</identifier><identifier>EISSN: 1879-0461</identifier><identifier>DOI: 10.1016/j.critrevonc.2009.01.001</identifier><identifier>PMID: 19186072</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Angiogenesis ; Angiogenesis Inhibitors - therapeutic use ; Animals ; Antibodies, Monoclonal - therapeutic use ; Antibodies, Monoclonal, Humanized ; Bevacizumab ; Biological and medical sciences ; Cancer ; Cell Hypoxia ; Enzyme Inhibitors - therapeutic use ; Hematologic and hematopoietic diseases ; Hematology, Oncology and Palliative Medicine ; Humans ; Hypoxia-inducible factor ; Hypoxia-Inducible Factor 1 - antagonists & inhibitors ; Hypoxia-Inducible Factor 1 - chemistry ; Hypoxia-Inducible Factor 1 - genetics ; Hypoxia-Inducible Factor 1 - metabolism ; Indoles - therapeutic use ; Intercellular Signaling Peptides and Proteins - metabolism ; Medical sciences ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Mustard Compounds - therapeutic use ; Neoplasms - blood supply ; Neoplasms - drug therapy ; Neovascularization, Pathologic - metabolism ; Phenylpropionates - therapeutic use ; Pyrroles - therapeutic use ; Review ; Tumors</subject><ispartof>Critical reviews in oncology/hematology, 2009-05, Vol.70 (2), p.93-102</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2009 Elsevier Ireland Ltd</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c523t-386f46e4c713ab1a6b80ab794df80348943631b01c5765f3133fac55ad113bb63</citedby><cites>FETCH-LOGICAL-c523t-386f46e4c713ab1a6b80ab794df80348943631b01c5765f3133fac55ad113bb63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.critrevonc.2009.01.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21391696$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19186072$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Otrock, Zaher K</creatorcontrib><creatorcontrib>Hatoum, Hassan A</creatorcontrib><creatorcontrib>Awada, Ahmad H</creatorcontrib><creatorcontrib>Ishak, Rim S</creatorcontrib><creatorcontrib>Shamseddine, Ali I</creatorcontrib><title>Hypoxia-inducible factor in cancer angiogenesis: Structure, regulation and clinical perspectives</title><title>Critical reviews in oncology/hematology</title><addtitle>Crit Rev Oncol Hematol</addtitle><description>Abstract Tumor hypoxia is a common feature of many cancers. A master regulator of hypoxic response is the transcription factor hypoxia-inducible factor-1 (HIF-1). It functions as a master regulator of oxygen and undergoes conformational changes in response to varying oxygen concentrations. In this paper, we review what has been described about HIF-1: its structure, its regulation and target genes, its role in cancer, and its implication for cancer therapy.</description><subject>Angiogenesis</subject><subject>Angiogenesis Inhibitors - therapeutic use</subject><subject>Animals</subject><subject>Antibodies, Monoclonal - therapeutic use</subject><subject>Antibodies, Monoclonal, Humanized</subject><subject>Bevacizumab</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Cell Hypoxia</subject><subject>Enzyme Inhibitors - therapeutic use</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Hypoxia-inducible factor</subject><subject>Hypoxia-Inducible Factor 1 - antagonists & inhibitors</subject><subject>Hypoxia-Inducible Factor 1 - chemistry</subject><subject>Hypoxia-Inducible Factor 1 - genetics</subject><subject>Hypoxia-Inducible Factor 1 - metabolism</subject><subject>Indoles - therapeutic use</subject><subject>Intercellular Signaling Peptides and Proteins - metabolism</subject><subject>Medical sciences</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>Mustard Compounds - therapeutic use</subject><subject>Neoplasms - blood supply</subject><subject>Neoplasms - drug therapy</subject><subject>Neovascularization, Pathologic - metabolism</subject><subject>Phenylpropionates - therapeutic use</subject><subject>Pyrroles - therapeutic use</subject><subject>Review</subject><subject>Tumors</subject><issn>1040-8428</issn><issn>1879-0461</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNksFu1DAQhiMEoqXlFVAucCLpTOw4DgckqIBWqsSh5WwcZ7LykrWDnazYt8fRLlTixMk-fDP-9fnPshyhREBxtS1NsHOgvXemrADaErAEwCfZOcqmLYALfJruwKGQvJJn2YsYtwDAuWieZ2fYohTQVOfZ95vD5H9ZXVjXL8Z2I-WDNrMPuXW50c5QyLXbWL8hR9HGd_n9HBYzL4He5oE2y6hn611i-tyM1lmjx3yiECcys91TvMyeDXqM9PJ0XmTfPn96uL4p7r5-ub3-cFeYumJzwaQYuCBuGmS6Qy06CbprWt4PEhiXLWeCYQdo6kbUA0PGUs661j0i6zrBLrI3x71T8D8XirPa2WhoHLUjv0QlGkSQTZVAeQRN8DEGGtQU7E6Hg0JQq121VY921WpXAapkN42-Or2xdDvqHwdPOhPw-gTomEQMIQm08S9XIWtRtGvYj0eOkpG9paCisZRk9zYkb6r39n_SvP9nyZ8P-EEHilu_BJeMK1SxUqDu1zasZYA2FQGSwd-BErNn</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>Otrock, Zaher K</creator><creator>Hatoum, Hassan A</creator><creator>Awada, Ahmad H</creator><creator>Ishak, Rim S</creator><creator>Shamseddine, Ali I</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090501</creationdate><title>Hypoxia-inducible factor in cancer angiogenesis: Structure, regulation and clinical perspectives</title><author>Otrock, Zaher K ; Hatoum, Hassan A ; Awada, Ahmad H ; Ishak, Rim S ; Shamseddine, Ali I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c523t-386f46e4c713ab1a6b80ab794df80348943631b01c5765f3133fac55ad113bb63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Angiogenesis</topic><topic>Angiogenesis Inhibitors - therapeutic use</topic><topic>Animals</topic><topic>Antibodies, Monoclonal - therapeutic use</topic><topic>Antibodies, Monoclonal, Humanized</topic><topic>Bevacizumab</topic><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Cell Hypoxia</topic><topic>Enzyme Inhibitors - therapeutic use</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Hypoxia-inducible factor</topic><topic>Hypoxia-Inducible Factor 1 - antagonists & inhibitors</topic><topic>Hypoxia-Inducible Factor 1 - chemistry</topic><topic>Hypoxia-Inducible Factor 1 - genetics</topic><topic>Hypoxia-Inducible Factor 1 - metabolism</topic><topic>Indoles - therapeutic use</topic><topic>Intercellular Signaling Peptides and Proteins - metabolism</topic><topic>Medical sciences</topic><topic>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</topic><topic>Mustard Compounds - therapeutic use</topic><topic>Neoplasms - blood supply</topic><topic>Neoplasms - drug therapy</topic><topic>Neovascularization, Pathologic - metabolism</topic><topic>Phenylpropionates - therapeutic use</topic><topic>Pyrroles - therapeutic use</topic><topic>Review</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Otrock, Zaher K</creatorcontrib><creatorcontrib>Hatoum, Hassan A</creatorcontrib><creatorcontrib>Awada, Ahmad H</creatorcontrib><creatorcontrib>Ishak, Rim S</creatorcontrib><creatorcontrib>Shamseddine, Ali I</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Critical reviews in oncology/hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Otrock, Zaher K</au><au>Hatoum, Hassan A</au><au>Awada, Ahmad H</au><au>Ishak, Rim S</au><au>Shamseddine, Ali I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypoxia-inducible factor in cancer angiogenesis: Structure, regulation and clinical perspectives</atitle><jtitle>Critical reviews in oncology/hematology</jtitle><addtitle>Crit Rev Oncol Hematol</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>70</volume><issue>2</issue><spage>93</spage><epage>102</epage><pages>93-102</pages><issn>1040-8428</issn><eissn>1879-0461</eissn><abstract>Abstract Tumor hypoxia is a common feature of many cancers. A master regulator of hypoxic response is the transcription factor hypoxia-inducible factor-1 (HIF-1). It functions as a master regulator of oxygen and undergoes conformational changes in response to varying oxygen concentrations. In this paper, we review what has been described about HIF-1: its structure, its regulation and target genes, its role in cancer, and its implication for cancer therapy.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>19186072</pmid><doi>10.1016/j.critrevonc.2009.01.001</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1040-8428 |
| ispartof | Critical reviews in oncology/hematology, 2009-05, Vol.70 (2), p.93-102 |
| issn | 1040-8428 1879-0461 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67110872 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Angiogenesis Angiogenesis Inhibitors - therapeutic use Animals Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized Bevacizumab Biological and medical sciences Cancer Cell Hypoxia Enzyme Inhibitors - therapeutic use Hematologic and hematopoietic diseases Hematology, Oncology and Palliative Medicine Humans Hypoxia-inducible factor Hypoxia-Inducible Factor 1 - antagonists & inhibitors Hypoxia-Inducible Factor 1 - chemistry Hypoxia-Inducible Factor 1 - genetics Hypoxia-Inducible Factor 1 - metabolism Indoles - therapeutic use Intercellular Signaling Peptides and Proteins - metabolism Medical sciences Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Mustard Compounds - therapeutic use Neoplasms - blood supply Neoplasms - drug therapy Neovascularization, Pathologic - metabolism Phenylpropionates - therapeutic use Pyrroles - therapeutic use Review Tumors |
| title | Hypoxia-inducible factor in cancer angiogenesis: Structure, regulation and clinical perspectives |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T07%3A02%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hypoxia-inducible%20factor%20in%20cancer%20angiogenesis:%20Structure,%20regulation%20and%20clinical%20perspectives&rft.jtitle=Critical%20reviews%20in%20oncology/hematology&rft.au=Otrock,%20Zaher%20K&rft.date=2009-05-01&rft.volume=70&rft.issue=2&rft.spage=93&rft.epage=102&rft.pages=93-102&rft.issn=1040-8428&rft.eissn=1879-0461&rft_id=info:doi/10.1016/j.critrevonc.2009.01.001&rft_dat=%3Cproquest_cross%3E67110872%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67110872&rft_id=info:pmid/19186072&rft_els_id=S1040842809000031&rfr_iscdi=true |