Hypoxia-inducible factor in cancer angiogenesis: Structure, regulation and clinical perspectives

Abstract Tumor hypoxia is a common feature of many cancers. A master regulator of hypoxic response is the transcription factor hypoxia-inducible factor-1 (HIF-1). It functions as a master regulator of oxygen and undergoes conformational changes in response to varying oxygen concentrations. In this p...

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Veröffentlicht in:	Critical reviews in oncology/hematology 2009-05, Vol.70 (2), p.93-102
Hauptverfasser:	Otrock, Zaher K, Hatoum, Hassan A, Awada, Ahmad H, Ishak, Rim S, Shamseddine, Ali I
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiogenesis Inhibitors - therapeutic use Animals Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized Bevacizumab Biological and medical sciences Cancer Cell Hypoxia Enzyme Inhibitors - therapeutic use Hematologic and hematopoietic diseases Hematology, Oncology and Palliative Medicine Humans Hypoxia-inducible factor Hypoxia-Inducible Factor 1 - antagonists & inhibitors Hypoxia-Inducible Factor 1 - chemistry Hypoxia-Inducible Factor 1 - genetics Hypoxia-Inducible Factor 1 - metabolism Indoles - therapeutic use Intercellular Signaling Peptides and Proteins - metabolism Medical sciences Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Mustard Compounds - therapeutic use Neoplasms - blood supply Neoplasms - drug therapy Neovascularization, Pathologic - metabolism Phenylpropionates - therapeutic use Pyrroles - therapeutic use Review Tumors
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Zusammenfassung:	Abstract Tumor hypoxia is a common feature of many cancers. A master regulator of hypoxic response is the transcription factor hypoxia-inducible factor-1 (HIF-1). It functions as a master regulator of oxygen and undergoes conformational changes in response to varying oxygen concentrations. In this paper, we review what has been described about HIF-1: its structure, its regulation and target genes, its role in cancer, and its implication for cancer therapy.
ISSN:	1040-8428 1879-0461
DOI:	10.1016/j.critrevonc.2009.01.001