A Microfluidic High-Resolution NMR Flow Probe

A Microfluidic High-Resolution NMR Flow Probe

A microfluidic high-resolution NMR flow probe based on a novel stripline detector chip is demonstrated. This tool is invaluable for the in situ monitoring of reactions performed in microreactors. As an example, the acetylation of benzyl alcohol with acetyl chloride was monitored. Because of the unco...

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Veröffentlicht in:Journal of the American Chemical Society 2009-04, Vol.131 (14), p.5014-5015
Hauptverfasser: Bart, Jacob, Kolkman, Ard J, Oosthoek-de Vries, Anna Jo, Koch, Kaspar, Nieuwland, Pieter J, Janssen, Hans (J. W. G.), van Bentum, Jan (P. J. M.), Ampt, Kirsten A. M, Rutjes, Floris P. J. T, Wijmenga, Sybren S, Gardeniers, Han (J. G. E.), Kentgens, Arno P. M
Format: Artikel
Sprache:eng
Schlagworte:
Acetates - chemistry
Acetylation
Benzyl Alcohol - chemistry
Cerebrospinal Fluid - chemistry
Chlorides - chemistry
Humans
Magnetic Resonance Spectroscopy - instrumentation
Magnetic Resonance Spectroscopy - methods
Metabolomics - instrumentation
Metabolomics - methods
Microfluidics - instrumentation
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Beschreibung
Zusammenfassung:A microfluidic high-resolution NMR flow probe based on a novel stripline detector chip is demonstrated. This tool is invaluable for the in situ monitoring of reactions performed in microreactors. As an example, the acetylation of benzyl alcohol with acetyl chloride was monitored. Because of the uncompromised (sub-Hz) resolution, this probe holds great promise for metabolomics studies, as shown by an analysis of 600 nL of human cerebrospinal fluid.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja900389x