Novel Application of Carbon Nanotubes for Improving Resolution in Detecting Human Serum Proteins with Native Polyacrylamide Gel Electrophoresis

This paper describes a novel application of carbon nanotubes for improving the resolution of a native PAGE in the detection of human serum proteins. Carbon nanotubes were functionalized and introduced into the gel of native PAGE system, and the electropherogram showed sharp, clear bands. Furthermore...

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Veröffentlicht in:	Nano letters 2009-04, Vol.9 (4), p.1320-1324
Hauptverfasser:	Guo, Yandong, Huang, Lingyun, Baeyens, Willy R. G, Delanghe, Joris R, He, Dacheng, Ouyang, Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Blood Proteins - chemistry Blood Proteins - isolation & purification Cross-disciplinary physics: materials science rheology Electrophoresis, Polyacrylamide Gel - methods Exact sciences and technology Humans Liver Diseases - blood Materials science Nanocrystalline materials Nanoscale materials and structures: fabrication and characterization Nanotubes Nanotubes, Carbon Physics
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Beschreibung
Zusammenfassung:	This paper describes a novel application of carbon nanotubes for improving the resolution of a native PAGE in the detection of human serum proteins. Carbon nanotubes were functionalized and introduced into the gel of native PAGE system, and the electropherogram showed sharp, clear bands. Furthermore, the separation of some most important proteins was improved, and the established method could be applied for the detection of sera from patients with liver diseases.
ISSN:	1530-6984 1530-6992
DOI:	10.1021/nl802935s