33S NMR cryogenic probe for taurine detection

33S NMR cryogenic probe for taurine detection

With the goal of a (33)S nuclear magnetic resonance (NMR) probe applicable to in vivo NMR on taurine-biological samples, we have developed the (33)S NMR cryogenic probe, which is applicable to taurine solutions. The NMR sensitivity gain relative to a conventional broadband probe is as large as 3.5....

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Veröffentlicht in:Review of scientific instruments 2009-03, Vol.80 (3), p.036106-036106
Hauptverfasser: Hobo, Fumio, Takahashi, Masato, Maeda, Hideaki
Format: Artikel
Sprache:eng
Schlagworte:
Cold Temperature
Computer-Aided Design
Equipment Design
Equipment Failure Analysis
Magnetic Resonance Spectroscopy - instrumentation
Reproducibility of Results
Sensitivity and Specificity
Sulfur Isotopes - analysis
Sulfur Isotopes - chemistry
Taurine - analysis
Transducers
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Zusammenfassung:With the goal of a (33)S nuclear magnetic resonance (NMR) probe applicable to in vivo NMR on taurine-biological samples, we have developed the (33)S NMR cryogenic probe, which is applicable to taurine solutions. The NMR sensitivity gain relative to a conventional broadband probe is as large as 3.5. This work suggests that improvements in the preamplifier could allow NMR measurements on 100 microM taurine solutions, which is the level of sensitivity necessary for biological samples.
ISSN:1089-7623
DOI:10.1063/1.3103573