Inhibitory Activity of Cyanidin-3-rutinoside on α-Glucosidase

Cyanidin-3-rutinoside, a natural anthocyanin, inhibited α-glucosidase from baker's yeast in dose-responsive manner. The IC50 value was 19.7 μM ± 0.24 μM, compared with the IC50 value of voglibose (IC50 = 23.4 ± 0.30 μM). Cyanidin-3-rutinoside was found to be a non-competitive inhibitor for yeas...

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Veröffentlicht in:	Journal of enzyme inhibition and medicinal chemistry 2004-08, Vol.19 (4), p.313-316
Hauptverfasser:	Adisakwattana, Sirichai, Ngamrojanavanich, Nattaya, Kalampakorn, Kanyarat, Tiravanit, Wilaiwon, Roengsumran, Sophon, Yibchok-Anun, Sirintorn
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Glucosidases - chemistry Anthocyanins - chemical synthesis Anthocyanins - chemistry Anthocyanins - pharmacology Cyanidin-3-rutinoside Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Enzyme kinetics Glycoside Hydrolase Inhibitors Inositol - analogs & derivatives Inositol - pharmacology Kinetics Molecular Structure Yeasts - enzymology α-Glucosidase inhibition
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Zusammenfassung:	Cyanidin-3-rutinoside, a natural anthocyanin, inhibited α-glucosidase from baker's yeast in dose-responsive manner. The IC50 value was 19.7 μM ± 0.24 μM, compared with the IC50 value of voglibose (IC50 = 23.4 ± 0.30 μM). Cyanidin-3-rutinoside was found to be a non-competitive inhibitor for yeast α-glucosidase with a Ki; value in the range of 1.31-1.56 × 10−5M. These results indicated that cyanidin-3-rutinoside could be classed as a new α-glucosidase inhibitor.
ISSN:	1475-6366 1475-6374
DOI:	10.1080/14756360409162443