Synthesis and Urease Enzyme Inhibitory Effects of Some Dicoumarols
Dicoumarols 1-10 with substituted phenyl residues at C-11 were synthesized and screened for their urease inhibition effects. All synthesized compounds showed varying degree of urease inhibitory activity ranging from IC50 = 74.30-91.35 μM.
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| Veröffentlicht in: | Journal of enzyme inhibition and medicinal chemistry 2004-08, Vol.19 (4), p.367-371 |
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| container_end_page | 371 |
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| container_issue | 4 |
| container_start_page | 367 |
| container_title | Journal of enzyme inhibition and medicinal chemistry |
| container_volume | 19 |
| creator | Khan, Khalid M. Iqbal, Sajid Lodhi, Muhammad A. Maharvi, Ghulam M. Perveen, Shahnaz Choudhary, M. I. Atta-ur-Rahman Chohan, Zahid H. Supuran, Claudiu T. |
| description | Dicoumarols 1-10 with substituted phenyl residues at C-11 were synthesized and screened for their urease inhibition effects. All synthesized compounds showed varying degree of urease inhibitory activity ranging from IC50 = 74.30-91.35 μM. |
| doi_str_mv | 10.1080/14756360409162452 |
| format | Article |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Taylor & Francis Journals Complete |
| subjects | 4-Hydroxycoumarin Derivatives Dicoumarol Dicumarol - analogs & derivatives Dicumarol - chemical synthesis Dicumarol - pharmacology Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology Fabaceae - enzymology Molecular Structure Urease - antagonists & inhibitors Urease - chemistry Urease Inhibitors |
| title | Synthesis and Urease Enzyme Inhibitory Effects of Some Dicoumarols |
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