UDP-glucose modulates gastric function through P2Y14 receptor-dependent and -independent mechanisms

P2Y receptors have been reported to modulate gastrointestinal functions. The newest family member is the nucleotide-sugar receptor P2Y14. P2ry14 mRNA was detected throughout the rat gut, with the highest level being in the forestomach. We investigated the role of the receptor in stomach motility usi...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2009-04, Vol.296 (4), p.G923-G930
Hauptverfasser:	Bassil, Anna K, Bourdu, Sophie, Townson, Karen A, Wheeldon, Alan, Jarvie, Emma M, Zebda, Noureddine, Abuin, Alejandro, Grau, Evelyn, Livi, George P, Punter, Lorraine, Latcham, Judith, Grimes, Angela M, Hurp, David P, Downham, Kelly M, Sanger, Gareth J, Winchester, Wendy J, Morrison, Alastair D, Moore, Gary B T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dose-Response Relationship, Drug Gastric Emptying - drug effects Gene Expression Regulation - physiology Lac Operon - genetics Lac Operon - physiology Mice Mice, Knockout Muscle Contraction - drug effects Muscle, Smooth - drug effects Rats Receptors, Purinergic P2 - genetics Receptors, Purinergic P2 - metabolism Receptors, Purinergic P2Y RNA, Messenger - genetics RNA, Messenger - metabolism Uridine Diphosphate Galactose - pharmacology Uridine Diphosphate Glucose - pharmacology
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Zusammenfassung:	P2Y receptors have been reported to modulate gastrointestinal functions. The newest family member is the nucleotide-sugar receptor P2Y14. P2ry14 mRNA was detected throughout the rat gut, with the highest level being in the forestomach. We investigated the role of the receptor in stomach motility using cognate agonists and knockout (KO) mice. In rat isolated forestomach, 100 microM UDP-glucose and 100 muM UDP-galactose both increased the baseline muscle tension (BMT) by 6.2+/-0.6 and 1.6+/-0.6 mN (P
ISSN:	0193-1857
DOI:	10.1152/ajpgi.90363.2008