Funny Current Downregulation and Sinus Node Dysfunction Associated With Atrial Tachyarrhythmia : A Molecular Basis for Tachycardia-Bradycardia Syndrome

Sinoatrial node (SAN) dysfunction is frequently associated with atrial tachyarrhythmias (ATs). Abnormalities in SAN pacemaker function after termination of ATs can cause syncope and require pacemaker implantation, but underlying mechanisms remain poorly understood. This study examined the hypothesis...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2009-03, Vol.119 (12), p.1576-1585
Hauptverfasser:	YEH, Yung-Hsin, BURSTEIN, Brett, XIAO YAN QI, SAKABE, Masao, CHARTIER, Denis, COMTOIS, Philippe, ZHIGUO WANG, KUO, Chi-Tai, NATTEL, Stanley
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood and lymphatic vessels Blood. Blood coagulation. Reticuloendothelial system Bradycardia - etiology Bradycardia - physiopathology Calcium Channels - genetics Calcium Channels - metabolism Cardiology. Vascular system Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Dogs Down-Regulation Electrophysiologic Techniques, Cardiac Heart Atria - physiopathology Heart Conduction System - physiopathology Ion Channels - genetics Ion Channels - metabolism Ion Transport Medical sciences Patch-Clamp Techniques Pharmacology. Drug treatments Potassium Channels - genetics Potassium Channels - metabolism RNA, Messenger - analysis Sinoatrial Node - physiopathology Syndrome Tachycardia - etiology Tachycardia - physiopathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Sinoatrial node (SAN) dysfunction is frequently associated with atrial tachyarrhythmias (ATs). Abnormalities in SAN pacemaker function after termination of ATs can cause syncope and require pacemaker implantation, but underlying mechanisms remain poorly understood. This study examined the hypothesis that ATs impair SAN function by altering ion channel expression. SAN tissues were obtained from 28 control dogs and 31 dogs with 7-day atrial tachypacing (400 bpm). Ionic currents were measured from single SAN cells with whole-cell patch-clamp techniques. Atrial tachypacing increased SAN recovery time in vivo by approximately 70% (P50% (P
ISSN:	0009-7322 1524-4539
DOI:	10.1161/CIRCULATIONAHA.108.789677