A Minor Experimental Stenosis in Porcine Descending Thoracic Aorta Affects the Spectral Content of Pressure Pulse Wave

: Objective: To carry out research into the possible changes of the spectral content of pressure pulse wave after the creation of an experimentally induced stenosis in the pig descending thoracic aorta. Methods: Eight healthy, normotensive Landrace pigs were subjected to thoracotomy under sterile conditions. At the upper segment of the descending thoracic aorta, a 5‐mm‐long circumferential symmetric constriction was imposed and stabilized; hence, a 15–20 mm Hg pressure gradient was established. Pressure tip catheters were used in order to monitor the pressure gradient. Blood flow disturbances were recorded through a bidirectional Doppler flow meter at pre‐ and poststenotic areas (A and B, respectively). Measurements were carried out before, 10 min after, and 90 days after the creation of the stenosis. The recorded waveforms were analyzed mathematically by using Fourier Transform, in order to determine their spectral component. Eight sham‐operated pigs were used as controls. Results: Fourier Transform analysis showed a significant increase (P